Broccoli Stem Extract Cream Shows Promise for Post-Acne Pigmentation: Study
Indonesia: Researchers have found in a new study that a 6% broccoli stem extract cream significantly improved pigmentation in post-acne macular scars, reducing melanin and erythema indices. Its good tolerability and high patient satisfaction suggest it may serve as a natural, safe alternative to conventional topical treatments.
The investigation published in Frontiers in Medicine has brought attention to an innovative, eco-conscious approach to treating post-acne macular scars. The research, led by Fitriend Syahputri from the Faculty of Medicine, Universitas Sumatera Utara, Indonesia, evaluated whether an extract made from broccoli stems — a part of the vegetable usually discarded as agricultural waste — could effectively reduce pigmentation and redness left behind by acne.
Post-acne macular scars, characterized by persistent discoloration rather than structural indentations, remain a common cosmetic concern. These dark or reddish marks can last for months, affecting appearance and self-esteem, and often prompt individuals to seek topical therapies. Broccoli stems, rich in compounds such as sulforaphane and flavonoids, offer antioxidant and anti-inflammatory properties that make them a promising candidate for addressing inflammation-induced pigmentation changes.
To explore this potential, the research team conducted a quasi-experimental study involving 30 adults aged 18 years and above who met specific inclusion criteria for post-acne macular scarring. Participants applied a 6% broccoli stem extract cream for eight weeks, with investigators assessing baseline and post-treatment melanin and erythema indices. Changes were analysed using the Wilcoxon signed-rank test, setting statistical significance at p < 0.05.
The study group primarily consisted of women in the late adolescent to young adult age range, a demographic often significantly affected by acne-related discoloration.
The study led to the following notable findings:
- After eight weeks of use, the cream produced clear improvements in post-acne macular scars.
- Both melanin and erythema indices showed statistically significant reductions, reflecting noticeable lightening of pigmentation and reduced inflammatory redness.
- The formulation was well tolerated, with no reports of irritation, dryness, sensitivity, or other adverse reactions.
- Its gentle profile makes it suitable for individuals with sensitive or post-inflammatory skin.
- All participants reported being satisfied with the product, reinforcing its potential for practical, real-world application.
The authors note that broccoli stems, often discarded during agricultural processing, represent a sustainable and underutilized resource. Their repurposing into dermatological formulations not only reduces waste but may also expand the range of natural treatment options available for acne-related pigmentation.
However, while the results are encouraging, the researchers acknowledge limitations. The study’s small sample size, relatively short duration, and lack of comparison with widely used treatments such as niacinamide or retinoids restrict broader generalization. They emphasize the need for larger, longer-term studies and head-to-head trials to validate the cream’s efficacy and determine its place among established therapies.
"Overall, the findings highlight that a 6% broccoli stem extract cream can effectively reduce pigmentation and redness in post-acne macular scars without causing adverse effects. With its natural ingredients, excellent tolerability, and high patient satisfaction, this plant-based formulation shows considerable promise as a safe alternative for managing acne-related hyperpigmentation," the authors concluded.
Reference:
Syahputri, F., Putra, I. B., & Jusuf, N. K. (2025). The effect of broccoli stem extract cream (Brassica oleracea L.) on macular scars post-acne. Frontiers in Medicine, 12, 1680933. https://doi.org/10.3389/fmed.2025.1680933
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