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  • Contezolid as...

Contezolid as effective as linezolid for treatment of complicated skin and soft tissue infections

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-04-04T09:00:09+05:30  |  Updated On 7 April 2022 11:29 AM IST
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Contezolid 800 mg q12h is as effective as linezolid for treatment of complicated skin and soft tissue infections (cSSTIs) in adults, but safer than linezolid in terms of haematological abnormalities, according to a recent study Journal of Antimicrobial Chemotherapy.

Contezolid is a novel oxazolidinone antibacterial agent for managing infections caused by aerobic and anaerobic Gram-positive bacteria including methicillin-resistant strains. A Phase III, multicentre, randomized, double-blind, active-controlled trial evaluated the efficacy and safety of contezolid versus linezolid in adults with complicated skin and soft tissue infections (cSSTIs).

Adult patients with cSSTI were randomized in a ratio of 1:1 to receive contezolid 800 mg or linezolid 600 mg q12h for 7–14 days. Clinical cure rate and safety were assessed at the test of cure (TOC) visit in the full analysis set (FAS) and clinical evaluable (CE) population. Non-inferiority was defined as a lower limit of the 95% CI around the treatment difference of clinical cure rates greater than −10%. Chinadrugtrials.org.cn registration identifier: CTR20150855.

Results of the study are:

Clinical cure rates at TOC indicated non-inferiority of contezolid 800 mg to linezolid 600 mg q12h for patients in the FAS with clinical evaluation, FAS, and CE populations: 92.8% (271/292) versus 93.4% (284/304) (difference −0.6%, 95% CI: −4.7% to 3.5%), 81.4% (271/333) versus 84.5% (284/336) (difference −3.1%, 95% CI: −8.8% to 2.6%) and 90.5% (267/295) versus 90.1% (282/313) (difference 0.4%, 95% CI: −4.3% to 5.1%). Contezolid and linezolid showed similar efficacy for the cSSTIs caused by methicillin-susceptible or methicillin-resistant Staphylococcus aureus. Contezolid demonstrated significant lower incidence of leucopenia (0.3% versus 3.4%) and thrombocytopenia (0% versus 2.3%) than linezolid. The frequency of treatment-emergent adverse events was comparable between the two groups.

Thus, Contezolid 800 mg q12h is as effective as linezolid for treatment of cSSTIs in adults, but safer than linezolid in terms of haematological abnormalities.

Reference:

A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections by Xu Zhao, et al. published in the Journal of Antimicrobial Chemotherapy

Keywords: Xu Zhao, Haihui Huang, Hong Yuan, Zhengyu Yuan, Yingyuan Zhang, efficacy and safety, of oral contezolid, linezolid, oral contezolid versus linezolid for soft tissue infections, Journal of Antimicrobial Chemotherapy


Journal of Antimicrobial Chemotherapyoral contezolidlinezolidskin and soft tissue infections
Source : Journal of Antimicrobial Chemotherapy
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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