- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Dupilumab therapy safe against Bullous Pemphigoid finds JAMA study
Dupilumab, a potentially novel therapy for bullous pemphigoid (BP), has shown encouraging results in a retrospective cohort study conducted by the National Autoimmune Bullous Diseases Cooperative Group of China. The study aimed to assess the efficacy and safety of dupilumab in patients with BP and identify factors affecting short-term and long-term outcomes. The findings were published in Journal American Medical Association.
Bullous pemphigoid is a rare and autoimmune skin disorder that causes large blisters on the skin's surface. It is often characterized by intense itching and discomfort. Conventional treatments have been limited, prompting researchers to explore novel therapies like dupilumab.
The retrospective cohort study spanned from January 2021 to July 2022 and involved 146 adult patients with BP. The participants received 300 mg of dupilumab every two weeks following an initial dose of 600 mg. To be eligible, patients had to show clinical signs of BP with supporting immunological or pathological evidence. Patients with drug-induced BP, less than four weeks of follow-up, or those who had received dupilumab or any other biologics within the last six months were excluded.
The primary outcome of the study was the proportion of patients who achieved disease control within four weeks. Disease control was defined as the absence of new lesions and itching, along with the healing of existing lesions. The results were promising, with 87.0% of patients achieving disease control within four weeks, and it took a median time of 14 days to achieve this. Additionally, 35.6% of patients achieved complete remission during the observation period, while 8.9% experienced relapses.
Throughout the follow-up period, the researchers observed rapid and sustained improvements in clinical indicators and laboratory results, including Bullous Pemphigoid Disease Area Index (BPDAI) scores, itching numerical rating scale (NRS) scores, serum anti-BP180 and anti-BP230 antibodies, total IgE levels, and eosinophil count.
Dupilumab treatment demonstrated a favorable safety profile in the study. The most common adverse events reported were infections and eosinophilia. Notably, the researchers found that patients with anti-BP180 antibody levels of at least 50 relative units (RU)/mL were associated with better disease control within four weeks.
Reference:
Zhao, L., Wang, Q., Liang, G., Zhou, Y., Yiu, N., Yang, B., Zhang, G., Li, W., Feng, S., Shang, P., Chen, X., Zhu, X., Zheng, J., Pan, M., & Wang, M. (2023). Evaluation of Dupilumab in Patients With Bullous Pemphigoid. In JAMA Dermatology. American Medical Association (AMA). https://doi.org/10.1001/jamadermatol.2023.2428
Neuroscience Masters graduate
Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751