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Dupilumab treatment may improve work productivity in patients with atopic dermatitis: Study
Japan: A recent study published in Experimental Dermatology has shed light on the impact of 1-year treatment with dupilumab on work productivity in Japanese patients with atopic dermatitis (AD).
The researchers showed that Dupilumab improved work productivity in Japanese patients with atopic dermatitis. They stated that long-term remission of pruritus and improved quality of life (QoL) are important for comprehensive improvement of work productivity.
Atopic dermatitis (also called eczema) is a chronic (long-lasting) disease that causes redness, inflammation, and irritation of the skin. The condition places a burden on work productivity. Recently, dupilumab received approval for atopic dermatitis, but its impact on work productivity in Japanese patients has not been reported. Furthermore, data is limited on the effect of long-term treatment with dupilumab on work productivity.
To fill this knowledge gap, Masahiro Kamata, Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan, and colleagues investigated the activity and work productivity in Japanese patients with moderate-to-severe atopic dermatitis, utilizing the Japanese version of the Work Productivity and Activity Impairment (WPAI-AD-Japan) questionnaire. Further, they also examined the impact of dupilumab on work productivity.
The study included adult moderate-to-severe AD patients treated with dupilumab for more than 12 months from 2020 to 2022 who filled out the WPAI-AD-Japan questionnaire. Twenty-eight adult AD patients were analysed.
The study led to the following findings:
- Absenteeism was low (mean: 5.3%), but presenteeism, work productivity loss and activity impairment were high (36.8%, 39.7%, and 48.9%, respectively).
- Significant positive correlations were observed between work productivity loss and visual analogue scale (VAS) score of pruritus and between activity impairment and dermatology life quality index (DLQI).
- Dupilumab treatment significantly reduced presenteeism, work productivity loss and activity impairment at 6 and 12 months.
- The extent of their amelioration was numerically higher at 12 months than at six months.
- The reduction rates in presenteeism, activity impairment, and work productivity loss were positively correlated with the reduction rates in DLQI and VAS score of pruritus at 12 months.
The findings showed that in Japanese AD patients, dupilumab improved work productivity.
"Long-term remission of pruritus and improved quality of life are important for comprehensive improvement of work productivity," the researchers wrote.
Reference:
Sakurai, E., Kamata, M., Uchida, H., Okada, Y., Suzuki, S., Takeshima, R., Ito, M., Watanabe, A., Mizukawa, I., Egawa, S., Chijiwa, C., Hiura, A., Fukaya, S., Hayashi, K., Fukuyasu, A., Tanaka, T., Ishikawa, T., & Tada, Y. (2024). Impact of 1-year treatment with dupilumab on work productivity in Japanese patients with atopic dermatitis. Experimental Dermatology, 33(2), e15022. https://doi.org/10.1111/exd.15022
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751