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  • Fatigue independently...

Fatigue independently associated with disease activity in SLE

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-25T19:30:13+05:30  |  Updated On 25 Sept 2022 9:55 PM IST
Fatigue independently associated with disease activity in SLE
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A recent study found that Fatigue and disease activity are independent factors as found using the Physician Global Assessment (PGA). The study was published in the journal RMD Open Rheumatic & Musculoskeletal Diseases.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, showing a broad spectrum of clinical manifestations, having a relapsing-remitting course, and can affect various organs or systems. Fatigue is one of the challenging manifestations of systemic lupus erythematosus. As it is not known if fatigue and disease activity are interdependent factors, researchers conducted a study to analyze if reported fatigue may bias the assessment of disease activity in SLE according to the Physician Global Assessment (PGA).

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Data were collected from patients from the Lupus BioBank of the upper Rhein database. A cross-sectional multicenter collection of detailed clinical and biological data was used. Participants had to fulfill the 1997 American College of Rheumatology criteria for SLE and the PGA (0–3 scale). Fatigue was assessed according to the Fatigue Scale for Motor and Cognitive Functions. Univariate and multivariate regression models were built to determine which variables were associated with the PGA.

Findings:

  • A total of 350 patients were included.
  • Of the total,89% were female with a median age of 42 years.
  • The median Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) score was 4 (IQR: 2–6).
  • Of these 350 patients, 257 (73%) reported significant fatigue.
  • The PGA was significantly associated with fatigue but not the SELENA-SLEDAI.
  • Both fatigue and SELENA-SLEDAI were independently associated with the PGA in two different multivariate models.
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Thus, the researchers concluded that Fatigue is independently associated with disease activity assessed using the PGA. To improve the reliability, they also suggested that the PGA should capture only objectively active disease manifestations.

For further reading: 10.1136/rmdopen-2022-002395

Mertz P, Piga M, Chessa E, et al. Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. RMD Open. 2022;8(2):e002395.

fatiguesystemic lupus erythematosusMotor and Cognitive FunctionsSafety of Estrogens in Lupus Erythematosus National AssessmentSystemic Lupus Erythematosus Disease Activity Indexdisease activity
Source : RMD Open Rheumatic & Musculoskeletal Diseases
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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