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First melanoma test to offer reassurance of low risk of cancer spread
![First melanoma test to offer reassurance of low risk of cancer spread First melanoma test to offer reassurance of low risk of cancer spread](https://medicaldialogues.in/h-upload/2020/10/14/750x450_135869-melanoma.webp)
A pioneering test which reliably predicts the spread or return of the most deadly form of skin cancer has been developed by a team of Newcastle scientists and clinicians.
The technological advance came as they made a scientific breakthrough in understanding the mechanism of skin cancer growth.
Led by Professor Penny Lovat at Newcastle University, UK, in association with the University spin out company AMLo Biosciences, the test offers reassurance for patients diagnosed with an early stage melanoma.
By applying the test - called AMBLor® - to the standard biopsy of the primary melanoma on its removal, patients who are at low risk of the disease reoccurring or spreading can be identified.
Melanoma growth
Melanoma is increasing worldwide and every year more than 16,000 people in the UK and 96,000 people in the US are diagnosed with the cancer.
Cory Inglis, 49, lives on the South Coast and AMBLor®is about to be used on his standard biopsy after a diagnosis of a melanoma on his back. He explained: "When you sit down with a dermatologist after the initial excision, you hear that it wasn't a mole, it was a melanoma. You are in a state of fear. It's overwhelming. At that moment a lot of the information that is provided is in very impenetrable, technical language. You ask yourself, what does it mean for me? To be able to have a test like this which provides you with result of the melanoma being low or at risk can help your medical team communicate the information in a way that is comprehensible, and importantly to help them to make the right subsequent decisions for you.
"A test, like AMBLor® which tells you that your tumour is genuinely low risk helps significantly with the anxiety of an already very stressful situation.
"Patients will understand what a low risk result means. If the result is at risk, it completely justifies the significant number of interactions that you will have with the dermatology team over a five year period. I don't see any downside in providing the dermatology team with more information about your melanoma."
Professor Penny Lovat added: "Our test offers a personalised prognosis as it more accurately predicts if your skin cancer is unlikely to spread. This test will aid clinicians to identify genuinely low risk patients diagnosed with an early stage melanoma and to reduce the number of follow up appointments for those identified as low risk, saving NHS time and money."
Phil Brady, Chief Operating Officer, British Skin Foundation said: "The British Skin Foundation is proud to support Prof Penny Lovat's ground-breaking melanoma research. The development of the AMBLor test can alleviate stress and anxiety for patients caused by this potentially deadly skin cancer, whilst increasing efficiency and reducing costs to the NHS."
Professor Nick Levell, Consultant Dermatologist & British Skin Foundation spokesperson who has not been involved in the research said: "This is excellent news. This new test for melanoma will help many people with skin cancer. People at low risk can be reassured and will not have to attend hospital so often for check-ups. This British Skin Foundation co-funded research is an important step forward in making care after melanoma more personal."
Currently, primary tumours are removed by surgery and pathologists study the biopsy under the microscope to determine the stage the skin cancer is at and the risk of it spreading (metastasis). Even if defined as low risk, the patient is followed up in clinic for as long as five years – and it is these patients that the test is able to identify.
The AMBRA1 and loricrin test is accredited by UKAS and is already available through a private referral service from the spin out company, AMBLo Biosciences. The test involves tissue sections from the standard biopsy being sent in the post to the lab for analysis. The Newcastle team have also submitted an application for the test to be made available on the NHS.
Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email:Â editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751