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  • Patch Test for Hair...

Patch Test for Hair Care Products Helps Identify Allergens, suggests study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-03-06T20:45:53+05:30  |  Updated On 7 March 2025 10:07 AM IST
Patch Test for Hair Care Products Helps Identify Allergens, suggests study
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Researchers in China have developed a specialized patch test for hair care products to identify allergens in patients experiencing hair loss, such as those with alopecia areata. This test supports personalized management and treatment strategies.

Hair loss significantly impacts an individual's appearance, self-confidence, quality of life, and social competitiveness. Over 250 million people in China suffer from hair loss, accounting for 18% of the population. To ensure the safe selection of topical hair products for hair loss patients, reduce the risks of allergies and irritation, and improve clinical efficacy and adherence, we developed a hair patch test based on clinical needs.

In this study, we explored the allergic situation of hair diseases through the test of patch products, which provided a strong basis for clinical personalized treatment. They designed a hair patch test to screen for allergens that are highly associated with hair diseases.

The experiment is based on screening of haptens and drugs commonly encountered by hair and scalp, covering hair dyes, scalp care products, and therapeutic drugs. The research subjects are patients diagnosed with hair related diseases (such as androgenetic alopecia, alopecia areata, etc.), ensuring that the samples are targeted. The allergen patch is fixed on the surface of the skin, with a contact time of 48 h, followed by recording and evaluating local skin reactions within 72 h.

The experiment aims to identify allergens that may cause or exacerbate hair diseases, providing a basis for the etiology research and treatment of related diseases. Results: Common allergens in daily hair care products include dodecyl polyglucoside (10.2% positivity rate) and Balsam of Peru (8.67% positivity rate). Cobalt chloride (56.63% positivity rate) and nickel sulfate (32.65% positivity rate) were prevalent metal semiallergens.

The positive rates of 5% minoxidil liniment were 22.96%, and the positive rate of 5% minoxidil tincture was 27.04%, indicating significant sensitization potential. Lowering minoxidil liniment concentration to 2% reduced positivity to 4.08%.

The positive rate of Hasonide solution mixed with 5% minoxidil tincture was 16.33%, while Hasinide solution and 5% minoxidil liniment were not positive, suggesting that the addition of both Hasonide solution could reduce the sensitization of 5% minoxidil tincture and minoxidil liniment. The increasing prevalence of hair disorders necessitates personalized treatment approaches. This study demonstrated the utility of patch testing with hair care products to investigate allergenic reactions, offering robust evidence for tailored clinical interventions. Future research should refine patch testing methodologies to better simulate real-world conditions and conduct larger-scale studies to optimize therapeutic strategies.

Reference:

Feng, C., Wang, Y., Yang, D. and Shen, H. (2025), Analysis of Common Treatment Drugs and Allergen Sensitization in Hair Loss Patients. J Cosmet Dermatol, 24: e16798. https://doi.org/10.1111/jocd.16798

Patch TestHairCareProductsHelpsIdentifyAllergenssuggestsstudy
Source : Journal of Cosmetic Dermatology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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