Psoriasis Closely Associated to Higher Risk of Kidney Stones Finds Study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-01-05T19:00:09+05:30 | Updated On 5 Jan 2024 7:00 PM IST

In a recent study published in The Journal of Dermatology uncovered a significant association between psoriasis, a chronic skin condition, and an increased risk of urolithiasis (kidney stones). The study involved a prospective analysis of a total of 67 psoriasis patients (PS group) and 65 individuals without psoriasis (NPS group) that aimed to explore potential links between psoriasis and urinary metabolic abnormalities.

The findings revealed that 19.4% of individuals in the PS group experienced stone events, compared to 7.7% in the NPS group which indicated a notable correlation between psoriasis and urolithiasis (P < 0.05).

The analysis of 24-hour urine samples proved crucial in understanding the metabolic nuances. The patients with psoriasis exhibited significantly lower median values of 24-hour citrate (P = 0.029) and higher median values of 24-hour urine uric acid (P = 0.005) when compared to their non-psoriatic counterparts.

Hypernatriuria was found to be significantly higher in the PS group (P = 0.027) by adding another dimension to the metabolic irregularities associated with psoriasis.

Also, the severity of psoriasis appeared to play a role in metabolic abnormalities, with hyperuricosuria detected in 10.4% of patients with severe disease compared to 1.5% in those with mild disease (P = 0.027).

These findings not only underscore a heightened risk of kidney stones in psoriasis patients but also shed light on specific metabolic factors contributing to this increased susceptibility. Hypocitraturia, hyperuricosuria, and hypernatriuria were found as key metabolic abnormalities associated with psoriasis, with hyperuricosuria associated to the severity of the disease.

The findings expand our understanding of the systemic impact of psoriasis and also emphasize the importance of holistic healthcare approaches for individuals suffering with this skin condition. The integration of dermatological considerations along with nephrological issue could prove important in managing and mitigating the risk of urolithiasis in psoriasis patients.

Source:

Oğuz, I. D., Oğuz, U., Usta, M., Kulaklı, S., Tosun, A., Demirelli, E., Akşan, B., Emecen, Ö., & Yüzüak, E. (2023). Relationship between psoriasis and urolithiasis. The Journal of Dermatology. https://doi.org/10.1111/1346-8138.17058

The Journal of Dermatologyurolithiasispsoriasis

Source : The Journal of Dermatology

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751