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  • Scalp neuropathy...

Scalp neuropathy associated with androgenetic alopecia: JAAD study

Dr Manoj Kumar NayakWritten by Dr Manoj Kumar Nayak Published On 2022-03-12T09:00:04+05:30  |  Updated On 2022-03-12T15:38:11+05:30
Scalp neuropathy associated with androgenetic alopecia: JAAD study

Scalp neuropathy associated with androgenetic alopecia: JAAD study- Androgenetic alopecia (AGA) is a common type of alopecia seen predominantly in males. It is a dermatological disorder due to sensitivity to dihydrotestosterone. Another possible contributing factor to AGA is the attachment of the arrector pili muscle (APM), the innervation of which may maintain follicular...

Scalp neuropathy associated with androgenetic alopecia: JAAD study- Androgenetic alopecia (AGA) is a common type of alopecia seen predominantly in males. It is a dermatological disorder due to sensitivity to dihydrotestosterone. Another possible contributing factor to AGA is the attachment of the arrector pili muscle (APM), the innervation of which may maintain follicular integrity. Inability to contract the APM might provoke hair loss. Therefore, the authors hypothesized that scalp neuropathy may play a role in AGA and recently published a study on this in the Journal of American Academy of Dermatology.

Scalp sensation n patents of AGA was evaluated on the midfrontal, left, and right frontotemporal recesses, vertex, and occipital regions of 62 men: 30 with Norwood- Hamilton 1 to 2 and 32 with Norwood-Hamilton $3 (clinically significant, AGA group). All participants were healthy with no hair transplants/scars, conditions affecting neural function, or inflammatory scalp conditions. None of the patients were using 5α-reductase inhibitors, minoxidil, or medications/treatments known to affect sensation.

Temperature discrimination testing consisted of exposure to glass vials containing either warm (480C-520C) or cold (130C-170C) water. Pressure sensitivity was tested by Semmes-Weinstein filaments of 0.07, 0.4, 2, and 4 g. Two point discrimination testing was done by applying discs with fixed 2- to 25-mm 2-point intervals. The optimal criterions (by receiver operator characteristic analysis) for pressure threshold and 3-point threshold were determined to be 0.4 g and 20 mm respectively.

Fisher's exact test was used to evaluate the association of AGA with scalp neuropathy. The data were analyzed for men older than 35 years to minimize confounding from age. Forty-two men were included; median age of the AGA group (n= 27) was 69 (interquartile range [IQR], 16) and the non-AGA group (n= 15) was 60 years (IQR, 15). Neuropathy at the vertex of the scalp (>0.4 g sensitivity) was significantly associated with AGA (P= 0.025). Forty-eight percent of men with AGA displayed neuropathy at the vertex compared with 13% of men without AGA. Neuropathy at the scalp vertex (>20 mm 2-point discrimination distance) was significantly associated with AGA (P= 0.002). Sixty-three percent of men with AGA displayed vertex neuropathy compared with 13% of men without AGA. Temporal neuropathy (>20 mm 2-point discrimination distance) was also associated with AGA. Sixty-three percent of men with AGA displayed neuropathy at the right frontotemporal recess compared with 20% of men without AGA (P= 0.008). Fifty-nine percent of men with AGA displayed neuropathy at the left frontotemporal recess compared with 20% of men without AGA (P= 0.015). No significant association was found between AGA and temperature discrimination. No differences were detected on the midfrontal or occipital scalp.

This is the 1st to find an association between scalp neuropathy and AGA. Scalp neuropathy might manifest as autonomic neuropathy and peripheral neuropathy, as autonomic nervous system controls the APM. The autonomic neuropathy hypothesis is consistent with the fact that disruption of the autonomic nervous system in leprosy triggers localized alopecia. This study shows association rather than cause and effect.

To conclude this study shows that scalp neuropathy could be associated with androgenetic alopecia but not in a cause and effect manner. Studies in a larger cohort ae required to give a robust evidence to support findings of this study.

Source- Cavanagh G, Goren A, Wambier CG. Scalp neuropathy in androgenetic alopecia. J Am Acad Dermatol. 2022 Jan;86(1):183-184. doi: 10.1016/j.jaad.2021.01.034. Epub 2021 Jan 19. PMID: 33476730.

Scalp neuropathy androgenetic alopecia AGA JAAD 
Source : Journal of American Academy of Dermatology
Dr Manoj Kumar Nayak
Dr Manoj Kumar Nayak

    MBBS

    Dr Manoj Kumar Nayak has completed his M.B.B.S. from the prestigious institute Bangalore medical college and research institute, Bengaluru. He completed his M.D. Dermatology from AIIMS Rishikesh. He is actively involved in the field of dermatology with special interests in vitiligo, immunobullous disorders, psoriasis and procedural dermatology. His continued interest in academics and recent developments serves as an inspiration to work with medical dialogues.He can be contacted at editorial@medicaldialogues.in.

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