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  • Secukinumab effective...

Secukinumab effective for treating pityriasis rubra pilaris: Study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-19T20:00:17+05:30  |  Updated On 19 Sept 2022 8:00 PM IST
Secukinumab effective for treating pityriasis rubra pilaris: Study
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USA: Secukinumab is a good therapy with favorable outcomes for pityriasis rubra pilaris (PRP) and deserves more research, suggests an article published in the British Journal of Dermatology.

Pityriasis rubra pilaris is a diverse collection of uncommon papulo-squamous illnesses distinguished by folliculo-centric keratinization. The incidence of PRP is bimodal, with equal gender preference. The pathophysiology of pityriasis rubra pilaris is unknown, however, IL-17 has been proven to play an important role. There are no effective immunomodulatory drugs for the treatment of PRP. As a result, Blake W. Boudreaux and colleagues undertook this study to assess the therapeutic effectiveness of secukinumab as well as to describe the transcriptome landscape of PRP and its response to IL-17A inhibition.

Twelve PRP patients were enrolled in an open-label study with secukinumab. Secukinumab was administered to patients throughout a 24-week period. The primary goal was to reduce the Psoriatic Area Severity Index score (PASI-75) by ≥75% from baseline to week 28. PASI-90, change in Dermatology Life Quality Index (DLQI)score, and change in Physician Global Assessment (PGA) were secondary objectives. At baseline and week 2, RNA sequencing was done on lesional and non-lesional skin samples. Differential gene expression and pathway enrichment were identified by comparing sample groups.

The key findings of this study were as follows:

1. At week 28, 6 patients (55%) reached PASI-75, whereas 3 patients (27%) achieved PASI-90.

2. Treatment resulted in substantial improvements in PGA and DLQI scores.

3. There were no significant treatment-related side effects. Secukinumab treatment restored transcriptional discrepancies between lesional and nonlesional skin.

4. Transcriptomic findings from nonresponsive patients imply that secukinumab resistance may be caused by the overactivity of innate immune pathways.

In conclusion, PRP is a transcriptionally diverse illness with a varied response to treatment. Future clinical trials should include agents targeting additional IL-17 isoforms and innate immune mediators.

Reference:

Boudreaux, B.W., Pincelli, T.P., Bhullar, P.K., Patel, M.H., Brumfiel, C.M., Li, X., Heckman, M.G., Pittelkow, M.R., Mangold, A.R. and Sluzevich, J.C. (2022), Secukinumab for the Treatment of Adult-Onset Pityriasis Rubra Pilaris: A Single-Arm Clinical Trial with Transcriptomic Analysis. Br J Dermatol. Accepted Author Manuscript. https://doi.org/10.1111/bjd.21708

secukinumabPityriasis Rubra PilarisBritish Journal of Dermatology
Source : British Journal of Dermatology
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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