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Weekly vitamin D supplementation improves VD status but fails to modify severity of atopic dermatitis in kids: Study
![Weekly vitamin D supplementation improves VD status but fails to modify severity of atopic dermatitis in kids: Study Weekly vitamin D supplementation improves VD status but fails to modify severity of atopic dermatitis in kids: Study](https://medicaldialogues.in/h-upload/2024/03/07/750x450_233801-atopic-dermatitis-in-children.webp)
Chile: A recent randomized controlled trial published in the Journal of the European Academy of Dermatology and Venereology has shed light on the effect of weekly vitamin D supplementation on the severity of atopic dermatitis (AD) and type 2 immunity biomarkers in children.
The researchers found that weekly vitamin D (VD) supplementation improved VD status but did not modify atopic dermatitis severity or type 2 immunity biomarkers compared to placebo among children with AD.
Vitamin D deficiency is frequent among patients with AD and is often associated with severity. However, randomized trials of VD supplementation in AD yielded equivocal results, and there is a lack of information regarding the impact of VD supplementation on type 2 immunity in AD patients.
To fill this knowledge gap, Arturo Borzutzky, Pontificia Universidad Católica de Chile, Santiago, Chile, and colleagues aimed to investigate the efficacy of VD supplementation to decrease the severity of AD and to alter type 2 immunity biomarkers.
For this purpose, the researchers conducted a randomized, double-blind, placebo-controlled trial that included 101 children with atopic dermatitis. They were randomly assigned to weekly oral vitamin D3 (VD3) or placebo for 6 weeks. The primary outcomes
performed in a randomized, double-blind, placebo-controlled trial. We randomly assigned 101 children with AD to weekly oral vitamin D3 (VD3) or placebo for 6 weeks. The primary outcome was the Severity Scoring of AD (SCORAD) change.
The study led to the following findings:
- The mean age of subjects was 6.3 ± 4.0 years, and baseline SCORAD was 32 ± 29. At baseline, 57% of children were VD deficient, with no difference between groups.
- Change in 25(OH)D was significantly greater with VD3 than placebo (+43.4 ± 34.5 nmol/L vs. +2.3 ± 21.2 nmol/L).
- SCORAD change at 6 weeks was not different between VD and placebo (−5.3 ± 11.6 vs. −5.5 ± 9.9).
- There were no significant between-group differences in change of eosinophil counts, total IgE, Staphylococcal enterotoxin specific IgE, CCL17, CCL22, CCL27, LL-37 or Staphylococcus aureus lesional skin colonization.
- Vitamin D receptor (VDR) gene single nucleotide polymorphisms FokI, ApaI, and TaqI did not modify subjects' response to VD supplementation.
In conclusion, weekly vitamin D supplementation improved VD status among children with atopic dermatitis but did not modify AD severity or type 2 immunity biomarkers compared to placebo.
Reference:
Borzutzky, A., Iturriaga, C., Pérez-Mateluna, G., Cristi, F., Cifuentes, L., Silva-Valenzuela, S., Vera-Kellet, C., Cabalín, C., Hoyos-Bachiloglu, R., Navarrete-Dechent, C., Cossio, M. L., Roy, C. L., & Camargo, C. A. Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial. Journal of the European Academy of Dermatology and Venereology. https://doi.org/10.1111/jdv.19959
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751