Acute liver injury ups risk of severe hypoglycemia, mortality in discharged diabetes patients

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-11-23T09:00:41+05:30 | Updated On 23 Nov 2022 4:26 PM IST

Taiwan: Findings from a recent study published in Diabetes Care showed that patients with type 2 diabetes and discharged with acute liver injury are at significantly more risk of mortality and severe hypoglycemia within 90 days and 365 days after discharge compared to patients discharged with other causes.

In the study, Fu-Shun Yen, Dr. Yen's Clinic, Taoyuan, Taiwan and colleagues aimed to compare the risks of severe hypoglycemia and mortality between patients with type 2 diabetes and discharged with and without acute liver injury.

For this purpose, the researchers identified patients with type 2 diabetes and hospitalization for acute liver injury and other causes from Taiwan's National Health Insurance Research Database. They compared the risks of severe hypoglycemia and mortality between the study and control groups using the multivariable-adjusted Cox proportional hazards models.

The authors reported the following findings:

The incidence rates and adjusted hazard ratios (aHRs) for severe hypoglycemia within 90 days and 365 days after discharge were 12.28 and 5.59/1,000 person-years (aHR 1.92) and 7.35 and 2.9/1,000 person-years (aHR 1.98) for patients discharged with and without acute liver injury, respectively.
The incidence rates and aHRs for mortality within 90 days and 365 days after discharge were 82.4 and 27.54/1,000 person-years (aHR 1.73) and 36.8 and 9.3/1,000 person-years (aHR 1.94) for patients discharged with and without acute liver injury, respectively.
The subgroup analysis of hypoglycemia risk in patients discharged with an acute liver injury revealed no significant interaction in risk factors of age, chronic kidney disease, and medications, except for sex difference, which has considerable interaction.

Findings from the cohort study showed that patients with T2D and those discharged with acute liver injury were at significantly higher risks of mortality and severe hypoglycemia within 90 and 365 days following the discharge than those released with other causes.

Reference:

Fu-Shun Yen, Ming-Chih Hou, Chun-Wei Pan, Jia-Sin Liu, Chih-Cheng Hsu, Chii-Min Hwu; The Risk of Severe Hypoglycemia and Mortality in Patients With Type 2 Diabetes and Discharged With Acute Liver Injury. Diabetes Care 2022; dc221349. https://doi.org/10.2337/dc22-1349

Diabetes Caretype 2 diabetesacute liver injuryhypoglycemia

Source : Diabetes Care

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751