Aortic femoral arterial stiffness gradient independent predictor of mortality among diabetes patients

Explaining the study background, researchers said that Arterial stiffness leads to additional cardiovascular risks in diabetic patients. It triggers the loss of vascular and myocardial compliance and promotes endothelial dysfunction.

They further said preventing arterial stiffness is a public health priority, and hence biomarkers may be highly significant in early prevention.

Considering these facts and figures, researchers in this study investigated the relationships between serum laboratory tests and pulse wave velocity (PWV) tests. They also study the associations between pulse wave velocity and all-cause mortality.

This study examined a panel of 33 blood biomarkers among diabetic populations in the Atherosclerosis Risk in Communities Study. The carotid-femoral (cfPWV) and femoral-ankle PWV (faPWV) were measured using an automated cardiovascular screening device. They calculated afSG [faPWV divided by cfPWV].

The study results could be demonstrated as follows:

• The biomarkers, including high-density lipoprotein cholesterol, glycated haemoglobin, high-sensitivity troponin T, cystatin C, creatinine, and albuminuria, significantly correlate with afSG and cfPWV among 1079 diabetic patients.
• Compared with the lowest tertile of afSG, the risk of all-cause mortality was lower in the highest tertile with a hazard ratio of 0.543.

Concluding further, they said some biomarkers related to blood glucose monitoring, myocardial injury, and renal function correlate with PWV significantly.

This demonstrates that these putative risk factors are atherosclerosis mechanisms in diabetic patients.

AfSG may be an independent predictor of mortality among diabetic populations, they said.

Further reading:

https://www.unboundmedicine.com/medline/citation/37329140/full_citation