Better glycemic control linked to beneficial effect on bone metabolism, finds study
According to a new study, Glycemic Control and Bone Metabolism Fasting blood glucose levels showed a negative correlation with markers of bone formation and resorption, including total serum procollagen type I N-terminal propeptide (PINP) and age-related type I cross-linked C-telopeptide (CTX). These findings suggest that better glycemic control may have a beneficial effect on bone metabolism.
This study aimed to compare bone metabolism markers between patients with hip fracture who had and did not have type 2 diabetes mellitus (T2DM).MethodsA total of 743 patients with hip fractures were enrolled in this case-control study and were further divided into type 2 diabetes mellitus and non-type 2 diabetes mellitus groups. Biochemical parameters, including fasting blood glucose, triglycerides, and total cholesterol, and bone metabolism parameters, including total serum procollagen type N-terminal propeptide and age-related type I cross-linked C-telopeptide, were collected and compared. Correlations between fasting blood glucose and triglyceride levels and bone metabolism parameters were assessed via Spearman correlation analysis.
Results: The fasting blood glucose and triglyceride levels in the type 2 diabetes mellitus group were significantly higher than those in the non-type 2 diabetes mellitusgroup. In addition, the total serum procollagen type N-terminal propeptide and age-related type I cross-linked C-telopeptide levels in the type 2 diabetes mellitus group were significantly lower than those in the non-type 2 diabetes mellitus group.
ConclusionsThe fasting blood glucose levels were negatively correlated with the total serum procollagen type N-terminal propeptide and age-related type I cross-linked C-telopeptide levels. In addition, our study speculated that good glycemic control may be beneficial for bone metabolism.
Reference:
Yang, Shaofeng, et al. "Does Type 2 Diabetes Affect Bone Metabolism in Patients After Hip Fracture? a Case-control Study." The Journal of International Medical Research, vol. 54, no. 1, 2026, p. 3000605251411081.
