Breath ketone analyzers non-invasively detect ketosis in adults with type 1 diabetes: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-09-27T11:00:41+05:30 | Updated On 27 Sept 2021 12:16 PM IST

USA: A recent study in the Journal of Diabetes and Its Complications has pointed out that a non-invasive breath ketone analyzer may be considered as a screening tool to rule out ketosis in people with type 1 diabetes (T1D). According to Halis Kaan Akturk and colleagues, it may be a good alternative for ketone monitoring in adults with T1D, but not in children.

Diabetic ketoacidosis (DKA) is a life threatening complication of type 1 diabetes. In order to prevent DKA, ketone monitoring is essential. Though, blood ketone monitoring is an accurate way of monitoring but is expensive. To look for a less expensive method, Dr. Akturk from University of Colorado, Aurora, CO,USA, and team aimed to assess the accuracy of a breath ketone analyzer to detect ketosis in adults and children with type 1 diabetes.

To fulfill their purpose, the researchers designed a proof-of-concept, prospective study comparing breath ketone analyzer and blood ketone meter to detect ketosis.

A total of 500 measurements from 19 adults and children with type 1 diabetes were analyzed. Based on the analysis, the researchers found the following:

There was a significant association between the breath ketone analyzer and blood ketone meter results in non-fasting adults, but not in children.
In adults, a cut-off of 3.9 PPM on the breath ketone analyzer maximized the Youden Index with an AUC of 0.73.
This cut-off for the breath ketone analyzer had 94.7% sensitivity and 54.2% specificity to detect ketosis (≥0.6 mmol/L in blood ketone meter).

Dr. Akturk, and colleagues concluded, "The breath ketone analyzer may be considered as a non-invasive screening tool to rule out ketosis in adults with type 1 diabetes."

Reference:

Halis Kaan Akturk, Janet Snell-Bergeon, Laura Pyle, Emily Fivekiller, Satish Garg, Erin Cobry, Accuracy of a breath ketone analyzer to detect ketosis in adults and children with type 1 diabetes, Journal of Diabetes and its Complications, 2021, 108030, ISSN 1056-8727, https://doi.org/10.1016/j.jdiacomp.2021.108030.

diabetic ketoacidosistype 1 diabetesJournal of Diabetes and Its Complications

Source : Journal of Diabetes and Its Complications

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751