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  • High Hemoglobin...

High Hemoglobin Glycation Index Linked to Increased Mortality in Heart Failure, reveals research

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-05-06T07:45:58+05:30  |  Updated On 6 May 2025 11:51 AM IST
High Hemoglobin Glycation Index Linked to Increased Mortality in Heart Failure, reveals research
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Researchers have identified in a new study that an elevated hemoglobin glycation index (HGI) is independently linked with higher risks of 30-day and 365-day mortality in heart failure (HF) patients admitted to the ICU. This research, using data from the MIMIC-IV database (2008-2019), emphasizes the prognostic significance of HGI, highlighting its potential utility in the identification of high-risk patients. The results indicate that the inclusion of HGI in clinical practice may enhance risk stratification and patient outcomes. The study was conducted by Ziyu Guo and colleagues published in BMC Diabetology & Metabolic Syndrome.

HGI is the observed-predicted difference for hemoglobin A1c (HbA1c) values. HbA1c has gained popularity in the management of diabetes, but it has not yet been explained completely in the context of HF prognosis. The aim of this study is to define the association between HGI and mortality in HF patients who are admitted to the ICU.

This study was conducted with a retrospective analysis of data from the MIMIC-IV database. The patients included in the study were previously admitted to intensive care for HF. A linear regression model was formulated to estimate predicted HbA1c from fasting blood glucose (FBG). The HGI value was established by the observed minus the predicted HbA1c. The major endpoints were 30 and 365-day all-cause mortality after admission.

Kaplan–Meier survival curves were utilized to contrast mortality rates between various HGI groups. Cox regression models and restricted cubic spline (RCS) analysis were used to evaluate the association between HGI and mortality risk. Subgroup and sensitivity analyses were used to confirm the results.

Key Findings

• 2,846 HF patients (40.1% male) were included.

• 10.7% (305 patients) of them died within 30 days, and 33.5% (954 patients) of them died within 365 days.

• Kaplan–Meier analysis also showed that a high HGI was significantly correlated with higher risk of mortality (log-rank P < 0.001).

• Those who had high HGI were significantly at a higher risk of 30-day (adjusted hazard ratio [aHR]: 2.36, 95% CI: 1.74–3.20, P < 0.001) and 365-day (aHR: 1.40, 95% CI: 1.16–1.68, P < 0.001) mortality.

• Every one-point rise in HGI was associated with 1.42-fold increased risk of 30-day mortality (aHR: 1.42, 95% CI: 1.28–1.57, P < 0.001) and 1.19-fold increased risk of 365-day mortality (aHR: 1.19, 95% CI: 1.11–1.68, P < 0.001).

• RCS analysis revealed an L-shaped nonlinear relationship between HGI and mortality (P for nonlinearity < 0.001), with an inflection point at HGI = -1.295.

• A high HGI value (> 0.709) was identified as a threshold for increased risk of mortality.

The study authors concluded that in critically ill heart failure patients admitted to ICU, high hemoglobin glycation index was strongly correlated with short-term and long-term mortality risks. The results indicate that HGI has the potential to be a useful prognostic indicator in clinical practice, facilitating the detection of high-risk patients and the best treatment strategies to maximize survival rates.

Reference:

Guo, Z., Li, Y., An, S. et al. Association between the haemoglobin glycation index and 30-day and 365-day mortality in patients with heart failure admitted to the intensive care unit. Diabetol Metab Syndr 17, 87 (2025).https://doi.org/10.1186/s13098-025-01661-4
BMC Diabetology & Metabolic SyndromeHemoglobin Glycation IndexHeart FailureICUMortalityPrognostic MarkerHbA1cFasting Blood GlucoseKaplan-MeierCox RegressionRisk Stratification
Source : BMC Diabetology & Metabolic Syndrome
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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