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  • Higher Potassium...

Higher Potassium Intake Linked to Lower Cardiovascular Risk in Diabetes, reveals research

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-01-02T08:45:40+05:30  |  Updated On 2 Jan 2025 12:02 PM IST
Higher Potassium Intake Linked to Lower Cardiovascular Risk in Diabetes,  reveals research
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Researchers have shown that higher potassium intake has been linked to significantly reduced risks of major cardiovascular events in patients with type 2 diabetes. A recent study was published in the journal Cardiovascular Diabetology conducted by Jian-Jun Liu and colleagues. MACE refers to a composite of myocardial infarction, stroke, and cardiovascular death. It has remained a main issue for patients diagnosed with type 2 diabetes.

The study aimed to examine the association of estimated potassium intake with the risk of MACE among patients with type 2 diabetes. The focus was on the determination of whether higher potassium intake could independently lower the risk of cardiovascular events.

The research comprised a discovery cohort of 1572 patients from a secondary hospital and a validation cohort of 1430 patients from the Chronic Renal Insufficiency Cohort (CRIC). Potassium intake was assessed by separate methods: application of the Kawasaki formula to the discovery cohort and 24 hour urine collection on the validation cohort. MACE was the key outcome, meaning myocardial infarction, stroke, and death from cardiovascular reasons. The people were stratified by levels of albuminuria, measured through the urine albumin-to-creatinine ratio (UACR) for possible interaction.

Key Results

Discovery Cohort Results:

• 341 MACE during a median 8.2 years of follow-up.

• Participants with the highest tertile of potassium intake had 34% lower risk of MACE than the lowest tertile, aHR (95% CI), 0.66 (0.49–0.89).

• The protective effect of potassium intake was more pronounced in participants with normal or moderately elevated albuminuria than in those with severely elevated albuminuria (UACR >300 mg/g, p<0.05).

Validation Cohort Results (CRIC):

• Higher potassium intake was independently associated with a 39% reduced risk of MACE among participants with diabetes and moderately elevated albuminuria (aHR [95% CI], 0.61 [0.42–0.90], top vs. lowest tertile).

• The consistency across both cohorts supports the reliability of the findings.

Albuminuria Interaction:

• The study showed that the benefits of higher potassium intake were significantly affected by albuminuria levels, highlighting its role in modulating cardiovascular risk.

A higher potassium intake, as estimated from urinary potassium excretion, was independently associated with a lower risk of MACE in patients with type 2 diabetes. These findings suggest that dietary strategies to increase potassium intake could provide significant cardiovascular protection, particularly in those with normal or moderately elevated albuminuria.

Reference:

Liu JJ, Zheng H, Liu S, Kwan TK, Gurung RL, Chan C, Lee J, Ang K, de Keizer J, Hadjadj S, Saulnier PJ, Chong MFF, Lim SC. Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation. Cardiovasc Diabetol. 2024 Dec 21;23(1):451. doi: 10.1186/s12933-024-02546-y. PMID: 39709437; PMCID: PMC11662727.

Cardiovascular Diabetologypotassium intakecardiovascular eventstype 2 diabetesMACEalbuminuria
Source : Cardiovascular Diabetology
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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