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  • Higher Satisfaction...

Higher Satisfaction with Once-Weekly Insulin Icodec Compared to Daily Doses in Type 2 Diabetes: ONWARDS Trials

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-10-24T09:00:02+05:30  |  Updated On 24 Oct 2024 9:00 AM IST
Higher Satisfaction with Once-Weekly Insulin Icodec Compared to Daily Doses in Type 2 Diabetes: ONWARDS Trials
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USA: A recent analysis from the ONWARDS clinical trials has revealed significant improvements in treatment satisfaction among individuals with Type 2 diabetes using once-weekly insulin icodec compared to traditional once-daily basal insulin. The findings underscore the potential benefits of this innovative treatment regimen in enhancing patient adherence and overall management of the condition.

"These findings indicate a higher level of treatment satisfaction and a clear preference for once-weekly insulin over the traditional once-daily basal insulin. The convenience of this regimen, along with patients' willingness to continue and recommend once-weekly treatment, was notably emphasized," the researchers wrote in Diabetes Research and Clinical Practice.

The study, which included patient-reported outcomes from ONWARDS 2 and 5, and physician surveys from ONWARDS 1, focused on the experiences of patients switching to insulin icodec. The ONWARDS phase 3a clinical trials compared the efficacy of once-weekly insulin icodec with once-daily basal insulin in individuals with type 2 diabetes. The analysis by William Polonsky, Behavioral Diabetes Institute, San Diego, CA, USA, and colleagues investigated the treatment-related experiences of participants from ONWARDS 5 and 2, and physicians from ONWARDS 1.

For this purpose, the researchers collected patient-reported outcomes exclusively during ONWARDS 5, which compared insulin icodec with a dosing guide app against once-daily basal analogs, and ONWARDS 2, which examined icodec versus once-daily insulin degludec. Additionally, treatment preferences and satisfaction from physicians participating in ONWARDS 1, where icodec was compared to once-daily insulin glargine U100, were gathered through an online survey.

The following were the key findings of the study:

  • In the ONWARDS 5 and 2 trials, there was a statistically significant increase in overall treatment satisfaction from baseline to the end of treatment for participants using insulin icodec or icodec with an app compared to those on once-daily alternatives. This boost in satisfaction is largely attributed to participants' willingness to continue and recommend the treatment.
  • In ONWARDS 2, an impressive 93.7% of users preferred the once-weekly regimen over the daily injections, primarily due to the convenience of fewer injections and greater ease of use.
  • Physicians involved in ONWARDS 1 expressed higher satisfaction with the once-weekly insulin regimen than with once-daily basal insulin, and they were more inclined to recommend the weekly injections.

The findings from insulin-naive and insulin-experienced participants with type 2 diabetes in the ONWARDS 5 and ONWARDS 2 trials, along with feedback from physicians in ONWARDS 1, reveal significant improvements in treatment satisfaction. Participants showed a strong preference for once-weekly basal insulin, leading to better adherence to treatment.

"These results highlight the potential for personalized approaches in diabetes care, making once-weekly insulin a viable option for individuals with type 2 diabetes," the researchers concluded.

Reference:

Polonsky, W., Benamar, M., Carstensen, L., Davies, M., Meller Donatsky, A., Franek, E., Kellerer, M., Philis-Tsimikas, A., & Goldenberg, R. (2024). Improved treatment satisfaction with once-weekly insulin icodec compared with once-daily basal insulin in individuals with type 2 diabetes: An analysis of patient-reported outcomes and participant interviews from ONWARDS 2 and 5 and a physician survey from ONWARDS 1. Diabetes Research and Clinical Practice, 217, 111885. https://doi.org/10.1016/j.diabres.2024.111885


Diabetes Research and Clinical Practiceinsulin icodectype 2 diabetespatient-reported outcomesphysician surveyONWARDS trial
Source : Diabetes Research and Clinical Practice
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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