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In Type 1 Diabetes, ketoacidosis not tied with poor long-term metabolic control in kids: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-01-07T09:00:42+05:30  |  Updated On 7 Jan 2022 9:01 AM IST
In Type 1 Diabetes, ketoacidosis not tied with poor long-term metabolic control in kids: Study
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The presence of diabetic ketoacidosis (DKA) at diabetes diagnosis is not associated with deteriorated long-term metabolic control in children, according to a study published in the BMC endocrine disorders.

Type 1 diabetes (T1D) is one of the most common metabolic diseases in the pediatric population worldwide. The global increase in the incidence of type 1 diabetes among children still remains at the level of 3 to 5% annually.

The study aimed to evaluate whether the presence of diabetic ketoacidosis (DKA) at diabetes diagnosis was associated with poorer metabolic control during a 5-year follow-up.

The study included children treated due to newly diagnosed T1D complicated with diabetic ketoacidosis (DKA)between 2010 and 2014 with a complete 5-year follow-up. In every case we performed individual matching for age, gender and BMI with a person without diabetic ketoacidosis (DKA) (nDKA) on recognition. We collected data regarding treatment modality, HbA1C, total daily insulin dose, basal insulin and BMI-SDS.

The Results of the study are as follows:

  • 85 children at the median age of 7.93 years had diabetic ketoacidosis (DKA) at diabetes diagnosis.
  • The median pH was 7.19.
  • Continuous subcutaneous insulin infusion (CSII) was used in 87% of participants in each group. No differences in HbA1C level (7,3%vs7,2%;p = .413) were noted after 5 years of disease duration.
  • The severity of ketoacidosis exerted no significant effect on HbA1C.
  • The method of insulin delivery at baseline was significantly associated with HbA1C levels after 5 years of observation, βCSII = − 1.46,95%CI[− 2.01 to − 0.92],p < .001.

Thus, the researchers concluded that the presence of diabetic ketoacidosis (DKA) at diabetes diagnosis is not associated with deteriorated long-term metabolic control in children using modern technologies. The early implementation of CSII into diabetes treatment may change the effect of diabetic ketoacidosis (DKA) and lead to a long-term HbA1C improvement.

Reference:

Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes? By Kowalczyk Emilia et al. published in the BMC Endocrine Disorders.

https://doi.org/10.1186/s12902-021-00882-8


in-patient diabeteschildrenadolescentscomplicationsdiabetic ketoacidosisdiabetes in childrendevicesself-managementbmc endocrine disorders
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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