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  • Lower levels of Free...

Lower levels of Free Triiodothyronine tied to Peripheral Neuropathy in Diabetics, suggests study

Written By : Dr.Niharika Harsha B |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-12-12T08:45:54+05:30  |  Updated On 12 Dec 2024 12:48 PM IST
Lower Free Triiodothyronine Risk Factor of Diabetic Peripheral Neuropathy in Type 2 Diabetes
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A groundbreaking study found that low levels of free Triiodothyronine are a risk factor for peripheral neuropathy in type 2 diabetics, as per results that were published in the journal Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.

Diabetic peripheral neuropathy (DPN) is a common cause of neuropathy worldwide. Literature shows that thyroid function abnormality can affect glucose metabolism, leading to complications in type 2 diabetics. Triiodothyronine (T3), one of the main active ingredients of thyroid hormones, is necessary for nerve survival. Previous research has shown that free triiodothyronine is a predictive factor for peripheral neuropathy in diabetics. As the role of free triiodothyronine (FT3) in nerve injury is not elucidated, researchers conducted a study to investigate the effect of FT3 on DPN, particularly on the conduction velocity of nerve fibers in T2DM patients without thyroid disease.

Also Read: Low Free Triiodothyronine Levels Linked to Increased Risk of Diabetic Peripheral Neuropathy in Type 2 Diabetes: Study

A cross-sectional study was carried out at the Department of Endocrinology, The First Affiliated Hospital of USTC, by recruiting 121 patients with T2DM. Among these, 64 were diagnosed with DPN, while 57 were not diagnosed with DPN despite having T2DM (controls). Neuropathy caused by any cause other than diabetes was excluded from the study. The participants were divided into the control group and the DPN group. Clinical parameters like age, gender, diabetes mellitus (DM) duration, and biochemical parameters were collected for each patient. Additionally, nerve conduction velocity was tested using neurophysiological methods, such as an electromyographic evoked potential meter. Correlation and regression analyses were employed to examine the relationship between the concentrations of FT3 and DPN. Binary logistic regression analysis was carried out to investigate the risk factors for DPN in T2DM patients. Multiple linear regression analyses were performed to explore further factors influencing nerve conduction fiber velocity.

Findings:

  • The DPN patients showed increased HbA1c and low-density lipoprotein cholesterol (LDL-C) levels (P=0.001 and 0.042), as well as decreased concentrations of FT3 (P=0.042) when compared to the controls.
  • FT3 levels were positively associated with the motor and sensory fibers conduction velocity of the Ulnar nerve and the motor conduction velocity of the Tibial nerve, with or without adjustment for HbA1c and LDL-C.
  • As per the multiple linear regression analysis, decreased FT3 levels may influence the motor and sensory fibers' conduction velocity of the Ulnar nerve and the motor conduction velocity of the Tibial nerve.
  • The binary logistic regression analysis demonstrated that decreased FT3 levels are one risk factor for DPN in T2DM patients.
Also Read: Image-guided thermal ablation effective treatment option for patients with papillary thyroid cancer patients: JAMA

Thus, this is the first study to report the association between FT3 and DPN in terms of specific nerve fiber injury in T2DM patients. The study concluded that lower FT3 concentration is a risk factor for DPN in T2DM patients. The study underscores the importance of monitoring the FT3 levels in diabetics for early identification of DPN. The authors also suggested that further research may be necessary to identify diagnostic criteria and treatment thresholds in diabetics with peripheral neuropathy.

Further reading: Chen Y, Sun L, Chen M, et al. Lower Free Triiodothyronine is a Risk Factor of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2024;17:4407-4415. Published 2024 Nov 25. doi:10.2147/DMSO.S489204.

Diabetes Metabolic Syndrome and Obesity: Targets and TherapyType 2 DiabetesYang ChenFree Triiodothyronine
Source : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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