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  • Oral Semaglutide...

Oral Semaglutide Lowers Cravings and Improves Metabolic Health in Type 2 Diabetes Patients: Study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-02-01T09:15:14+05:30  |  Updated On 1 Feb 2025 1:57 PM IST
Oral Semaglutide Lowers Cravings and Improves Metabolic Health in Type 2 Diabetes Patients: Study
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A new study published in the journal Diabetes & Vascular Disease Research has found that oral semaglutide reduces total energy intake and changes in the food preference in patients with type 2 diabetes. Diet control is one of the most important management strategies for diabetes, but it is hard for many patients to resist cravings for high-calorie foods. Semaglutide is a GLP-1 RA, and it has been reported to be involved in the regulation of blood sugar levels and weight loss. This study was conducted by Junya H. and colleagues.

The study entailed analysis of data involving 75 patients with type 2 diabetes who received oral semaglutide. The main outcome was the change in the BDHQ score after a three-month period of treatment. Secondary outcomes included changes in the CoEQ, HbA1c, and body mass index, all within the same period.

Main Results

• Participants: The study included 23 participants whose age was at median 64.0 years old, with mean BMI at baseline of 26.9 kg/m², and HbA1c at the onset of 7.6% (59 mmol/mol).

• Total energy decreased: Total energy intake significantly dropped according to the BDHQ outcome.

• Carbohydrates decreased more: The decreases in the consumptions of nutrients were greatest on carbohydrates.

Some food cravings also decreased: There were significant drops in cravings on CoEQ by sweet foods:

• Chocolate and chocolate-flavored foods

• Carbohydrates

The study also reported lower scores for:

• Meal satisfaction

• Frequency and intensity of food cravings

• Difficulty resisting cravings

• Frequency of eating in response to cravings

Improved metabolic outcomes: Both HbA1c and BMI significantly decreased after three months of treatment.

Researchers concluded that oral semaglutide improves blood glucose control and diminishes body weight while also modulating food preference in patients with type 2 diabetes. Since semaglutide would reduce total energy intake, carbohydrate intake, and food cravings, it can potentially lead the patient to follow healthier eating behaviors, thereby managing diabetes better as well as eventually leading to positive long-term outcomes.

Reference:

Hironaka J, Ushigome E, Kondo Y, et al. Changes in food preferences after oral semaglutide administration in Japanese patients with type 2 diabetes: KAMOGAWA-DM cohort. Diabetes and Vascular Disease Research. 2025;22(1). doi:10.1177/14791641251318309

Diabetes & Vascular Disease ResearchSemaglutidetype 2 diabetesfood preferencescarbohydrate intakeappetite controldietary behaviorHbA1c reductionweight managementGLP-1 receptor agonistenergy intake reduction
Source : Diabetes & Vascular Disease Research
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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