Regular high vitamin D supplementation can lower diabetes risk, finds study
Daily vitamin D supplementation to maintain a serum 25(OH)D level greater than 100 nmol/L is a promising approach to reducing the risk of diabetes in adults with prediabetes, suggests the findings of a recent research, published in the Diabetes Care.
Over the past decade, vitamin D has emerged as a possible determinant of risk of type 2 diabetes, and vitamin D supplementation has been hypothesized as a potential intervention to lower diabetes risk. Observational studies strongly support an association between high blood 25-hydroxyvitamin D [25(OH) D] levels and a lower risk of developing diabetes, especially in people at risk for type 2 diabetes.
The Vitamin D and Type 2 Diabetes (D2d) study was a randomized placebo-controlled trial conducted to test whether vitamin D supplementation reduces the risk of diabetes among adults at high risk for type 2 diabetes. So, with this aim Bess Dawson-Hughes et al, carried out the D2d study comparing the effect of daily supplementation with 100 mg (4,000 units) of vitamin D3 versus placebo on new-onset diabetes in adults with prediabetes.
Eligible participants met at least two of three glycemic criteria for prediabetes as defined by the 2010 American Diabetes Association (ADA) guidelines. Intratrial vitamin D exposure was calculated as the cumulative rolling mean of annual serum 25(OH)D measurements.
On data analysis, the following results emerged.
· There was an interaction of trial assignment with intratrial 25(OH)D level in predicting diabetes risk (interaction P 5 0.018).
· The hazard ratio for diabetes for an increase of 25 nmol/L in intratrial 25(OH)D level was 0.75 (95% CI 0.68–0.82) among those assigned to vitamin D and 0.90 (0.80–1.02) among those assigned to placebo.
· The hazard ratios for diabetes among participants treated with vitamin D who maintained intratrial 25(OH)D levels of 100–124 and ‡125 nmol/L were 0.48 (0.29– 0.80) and 0.29 (0.17–0.50), respectively, compared with those who maintained a level of 50–74 nmol/L.
"In the D2d study of adults with prediabetes, trial participants who maintained higher intratrial serum 25(OH)D levels during follow-up had a reduced risk of diabetes, with the greatest risk reduction occurring at intratrial 25(OH)D levels >125 nmol/L and partial risk reduction at levels of 100–124 nmol/L. The inverse association between higher intratrial 25(OH)D levels and diabetes risk was significant only among trial participants who were assigned to the trial intervention of 100 mg (4,000 units) per day of vitamin D3."wrote the team.
For full story follow the link:https://doi.org/10.2337/dc20-1765
primary source: Diabetes Care
