Resveratrol may inhibit metabolism and reduce blood platelet function in type 2 diabetes: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-04-28T11:00:19+05:30 | Updated On 28 April 2022 12:10 PM IST

Poland: A recent study in the journal Nutrients shows that the resveratrol-induced inhibition of platelet metabolism and TXA2 release may reduce platelet function and thrombus formation in type 2 diabetes patients. This implies the benefit of resveratrol for preventing vascular complications as a future complementary treatment in aspirin-resistant diabetic patients.

Chronic hyperglycemia can lead to vascular complications in diabetes. Resveratrol exerts anti-diabetic and anti-platelet action. Anna Michno, Department of Laboratory Medicine, Medical University of Gdańsk, Gdansk, Poland, and colleagues aimed to investigate the effects of resveratrol on metabolism and the function of blood platelets under static and in in vitro flow conditions in patients with type 2 diabetes.

For this purpose, the researchers obtained blood from 8 healthy volunteers and 10 patients with type 2 diabetes incubated with resveratrol and perfused over collagen-coated capillaries. Isolated blood platelets were incubated with resveratrol and activated by collagen for assessing platelet function, ATP release, metabolism, TXA2 production, glutathione content, and lipid peroxidation.

The study led to the following findings:

In the type 2 diabetes group, plasma glucose and fructosamine concentrations were significantly higher than in the healthy group.
In in vitro studies, collagen-induced thrombi formation in the blood of diabetic patients was 33% higher than in the healthy group.
Resveratrol reduced thrombi by over 50% in the blood of healthy and diabetic patients. TXA₂ production was 47% higher in diabetic platelets than in the healthy group.
Resveratrol reduced TXA₂ release by 38% in healthy platelets and by 79% in diabetic platelets.
Resveratrol also reduced the activities of enzymes responsible for glycolysis and oxidative metabolism in the platelets of both groups.

"Resveratrol-induced inhibition of platelet metabolism and TXA2 release may lead to a reduction of platelet function and thrombus formation in type 2 diabetes patients," wrote the authors. "Resveratrol, therefore, may be beneficial to prevent vascular complications as a future complementary treatment in aspirin-resistant diabetic patients."

Reference:

Michno, Anna et al. "Resveratrol Inhibits Metabolism and Affects Blood Platelet Function in Type 2 Diabetes." Nutrients vol. 14,8 1633. 14 Apr. 2022, doi:10.3390/nu14081633

Nutrients journaltype 2 diabetesresveratrolblood platelets

Source : Nutrients journal

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751