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  • Statins use may...

Statins use may Increase Neuropathy risk Among T2DM patients, Metformin decreases it

Written By : MD Bureau |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-12-25T10:00:43+05:30  |  Updated On 25 Dec 2021 10:01 AM IST
Statins use may Increase Neuropathy risk Among T2DM patients, Metformin decreases it
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The prevalence of type 2 diabetes mellitus (T2DM) and dyslipidemia are increasing with increased population ageing worldwide. Statins and metformin are commonly used medications for the treatment of dyslipidemia and diabetes. A recent study explored the effect of statins and metformin on the incidence of neuropathy among patients with T2DM. The study findings were published in the World Journal of Clinical Cases on November 26, 2021.

Diabetic neuropathy is one of the most common chronic complications in patients with type 2 diabetes mellitus. It is a chronic microvascular complication in patients with T2DM that depends on the duration and severity of T2DM. Some observational studies have shown that statin and metformin were associated with an increased risk of neuropathy. However, little is known about the impact of commonly used medications, i.e. statins and metformin, on neuropathy development in patients with T2DM. Therefore, researchers of the Konkuk University Medical Center, Seoul KS013, South Korea, conducted a study to evaluate the incidence of neuropathy among patients with T2DM associated with statin and metformin therapies.

In the present study, the researchers used the Korean Health Insurance Review and Assessment patient sample data from 2016 and 2017. They included patients with T2DM (n=34964)and no complications (n=35887) were divided into statin/metformin/statin + metformin users and non-users.They determined neuropathy by the International Statistical Classification of Diseases and Related Health Problems, 10th revision codes and concomitant prescriptions for anticonvulsants or antidepressants. They used logistic regression analyses to examine the associations between statin/metformin/statin + metformin therapies and the incidence of neuropathy.

Key findings of the study:

  • Upon analysis, the researchers found that statin therapy was associated with increased risks of neuropathy in 2016 and 2017 [PS-matched odds ratio (OR) = 1.22; PS-matched OR = 1.17].
  • They also found that metformin therapy was associated with reduced risks of neuropathy in 2016 and 2017 (PS-matched OR = 0.30; PS-matched OR = 0.44).
  • They found no significant association in combined statin + metformin therapy with neuropathy in 2016 or 2017 (PS-matched OR = 0.85; PS-matched OR = 0.95).

The authors concluded, "Statin therapy enhanced the risk of neuropathy in patients with T2DM, whereas metformin therapy reduced this risk. Combined statin + metformin therapy did not have a significant impact on the incidence of neuropathy. Therefore, when prescribing statin therapy for patients with T2DM, physicians should assess the potential for neuropathy development and consider the addition of metformin to reduce this risk."

For further information:

DOI: 10.12998/wjcc.v9.i33.10198


Type 2 Diabetes mellitusNeuropathiesHydroxymethylglutaryl-CoA reductase inhibitorsMetforminStatinsKorean Health Insurance dataWorld Journal of Clinical Cases
Article Source :   World Journal of Clinical Cases
MD Bureau
MD Bureau

    Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers.  Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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