Tirzepatide may reduce CVD Risk in Non-Diabetic Overweight Patients

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-12-20T21:30:16+05:30 | Updated On 21 Dec 2023 12:08 PM IST

The outcomes from the SURMOUNT-1 phase 3 trial found tirzepatide to effectively manage the long-term risk of atherosclerotic cardiovascular disease (ASCVD) among individuals with obesity or overweight but with no diabetes. The findings were published in the Journal of Diabetes, Obesity and Metabolism.

The study assessed the efficacy and safety of tirzepatide in adults with a body mass index (BMI) of ≥30 or ≥27 kg/m² and at least one weight-related complication, excluding diabetes. Participants were randomly assigned to receive tirzepatide at varying doses (5/10/15 mg) or a placebo. Over 72 weeks, cardiometabolic variables were scrutinized and 10-year ASCVD risk scores were calculated using the American College of Cardiology/American Heart Association risk engine.

The tirzepatide-treated groups exhibited reductions in cardiometabolic variables throughout the study duration. In the 2461 participants without a history of ASCVD, the baseline median risk score, ranging from 1.5% to 1.6%, showed no significant differences. The relative change in ASCVD risk from baseline to week 72 was remarkably greater for the tirzepatide cohort (-23.5% to -16.4%) compared to the placebo group (12.7%; P < 0.001). This trend was found true for participants with intermediate-to-high baseline risk by showing a significantly greater relative change (P < 0.05) and underlining the potential impact of tirzepatide in this subgroup.

Tirzepatide treatment significantly reduced the 10-year predicted risk of ASCVD in individuals with obesity or overweight but without diabetes. These findings deepen our understanding of the potential of tirzepatide and also helps in addressing cardiovascular risks in a population facing the challenges of excess weight.

Reference:

Hankosky, E. R., Wang, H., Neff, L. M., Kan, H., Wang, F., Ahmad, N. N., Griffin, R., Stefanski, A., & Garvey, W. T. (2023). Tirzepatide reduces the predicted risk of atherosclerotic cardiovascular disease and improves cardiometabolic risk factors in adults with obesity or overweight: SURMOUNT‐1 post hoc analysis. In Diabetes, Obesity and Metabolism (Vol. 26, Issue 1, pp. 319–328). Wiley. https://doi.org/10.1111/dom.15318

Source : Diabetes, Obesity and Metabolism

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751