- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Tobacco Use Associated with latent autoimmune diabetes in genetically susceptible individuals
![Tobacco Use Associated with latent autoimmune diabetes in genetically susceptible individuals Tobacco Use Associated with latent autoimmune diabetes in genetically susceptible individuals](https://medicaldialogues.in/h-upload/2023/04/20/750x450_207911-stanford-neuromodulation-therapy-4.webp)
Sweden: An original article published in Diabetes Care Journal, American Diabetes Association, written by Jessica Edstorp from the Institute of Environmental Medicine, Karolinska Institute, has addressed the role of genetic susceptibility for latent autoimmune diabetes (LADA) and type 2 diabetes in mediating the relationship between tobacco use and the onset of LADA or type 2 diabetes.
They found no role of genetic susceptibility in increasing type 2 diabetes risk in persons with a history of tobacco use. However, LADA risk increase in individuals with genetic susceptibility and tobacco use.
Previous studies have mentioned the association between Smoking and Swedish smokeless tobacco (snus) and latent autoimmune diabetes in adults with LADA and T2D.
Considering this background, researchers investigated the role of genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) using data from two population-based Scandinavian studies.
The study results could be summarised as follows:
- The RR of LADA was elevated in high IR-GRS heavy smokers with≥15 pack-year having an RR of 2.01 and tobacco users with ≥15 box/pack-years having an RR of 2.59.
- Heavy smokers had additive interaction between T2D-GRS and smoking, snus, and total tobacco use.
- The additional risk posed by tobacco use did not differ based on Genetic Risk Score categories in T2D.
Concluding further, they said that use of Tobacco use poses a higher risk of LADA in those with a genetic susceptibility to T2D and insulin resistance.
Based on the findings of our study, we do not report the importance of genetic susceptibility in influencing the increased incidence of T2D tied to tobacco usage.
Further reading:
Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study. Diabetes Care dc222284. https://doi.org/10.2337/dc22-2284
BDS, MDS in Periodontics and Implantology
Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751