Ultrasound Localization Microscopy promising for early diagnosis of Diabetic Kidney Disease

Written By : Dr. Mahalakshmi Sivashankaran |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-05-16T20:00:37+05:30 | Updated On 16 May 2023 8:00 PM IST

China: Researchers have found that ultrasound localization microscopy (ULM) may be useful for early diagnosis of diabetic kidney disease (DKD). The study was published in the Journal of Ultrasound in Medicine (JUM).

The goal of this study is to detect hemodynamic changes in microvessels in the early stages of diabetic kidney disease (DKD) and to assess the feasibility of ultrasound localization microscopy (ULM) in DKD early detection.

The study used a rat model of diabetic kidney disease induced by streptozotocin. Conventional ultrasound, contrast-enhanced ultrasound, and ULM were used to collect and analyze data. The kidney cortex was divided into four segments, and the blood flow velocities of arteries and veins were separately calculated and compared using the Mann-Whitney U test.

The study revealed the following clinical findings:

1. ULM detected lower arterial velocity in segments 2, 3, and 4 in DKD rats compared to normal rats.

2. Overall mean arterial velocity was also lower in DKD rats.

3. Venous velocity of segment 3 and overall mean venous velocity was higher in DKD rats.

4. Arterial velocity gradient was lower in DKD rats compared to normal rats.

The findings of this study suggest that ULM may be a non-invasive and feasible approach to early DKD diagnosis. Further studies are needed to validate these findings in humans, but this research could pave the way for the development of new diagnostic tools and treatment strategies for DKD.

The researchers added that “The study shows promising results in the use of ULM for the early detection of DKD. With further research and validation, this technique may become a valuable tool for clinicians in the fight against DKD and its associated complications.”

Reference:

Zhang H., Huang L., Yang Y., Qui L., He Q., Liu J., Qian L., Luo J.; Evaluation of Early Diabetic Kidney Disease Using Ultrasound Localization Microscopy; Journal of Ultrasound in Medicine (JUM); 2023; doi: https://doi.org/10.1002/jum.16249

Ultrasound Localization MicroscopyDiabetic Kidney Diseaseearly kidney diseaseearly diagnosistype 2 diabetesDKDULMJournal of Ultrasound in Medicine

Article Source : Journal of Ultrasound in Medicine

Dr. Mahalakshmi Sivashankaran

Dr. Mahalakshmi Sivashankaran joined Medical Dialogues as an Intern in 2023. She is a BDS graduate from Manipal College of Dental Sciences, Mangalore Batch 2022, and worked as a Junior Resident at VMMC & Safdarjung Hospital at the Department of Dental Surgery till January 2023. She has completed a Diploma in Executive Healthcare management from the Loyola Institute of Business Administration, developing skills in Healthcare Management and Administration. She covers several medical specialties including Dental, ENT, Diagnostics, Pharmacology, Neurology, and Cardiology.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751