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Vitamin D supplementation beneficial for glucose markers among postmenopausal women
The increase in the prevalence of type 2 diabetes is closely linked to the upsurge in obesity. Obesity and associated metabolic syndrome is also linked to impaired glucose tolerance. Epidemiological studies have linked low vitamin D levels to the pathogenesis of diabetes and also supported the favorable effects of adequate vitamin D intake on reducing the risk of T2D.
Dr Hao L et al. and colleagues have recently found in a new study that among postmenopausal women, Vitamin D is beneficial for glucose markers but not obesity.
The findings of the study have been published in the Journal Clinical Therapeutics.
The effect of vitamin D effect on glucose markers and obesity in postmenopausal women remains controversial. There needs to be more data available on the dosage and duration of vitamin D for optimal efficacy in postmenopausal women. This background was researched in the present study using databases without language restrictions. The data was collected from PubMed/MEDLINE, Web of Science, EMBASE, and Scopus.
A total of Nine eligible articles with 12 comparisons qualified for the final quantitative analysis and the findings could be summarised as follows:
- An overall decrease was noted in fasting blood glucose, homeostatic model assessment for insulin resistance, insulin and glycosylated haemoglobin with a weighted mean difference of -3.56 mg/dL; -1.168 mm; -2.26 units; and -0.41%, respectively after vitamin D administration in postmenopausal women.
- In subgroup analyses, there was a notable decrease in fasting blood glucose when the intervention course was ˃6 months and dosage ≤1000 IU/d with WMD, -3.48 mg/dL.
- Vitamin D was not associated with body mass index, weight, or waist circumference.
The researchers have concluded that Vitamin D is beneficial for glucose markers but not obesity in postmenopausal women.
However a personalized dosage plan for vitamin D should be implemented for postmenopausal women based on the target clinical outcomes.
Further reading:
BDS, MDS in Periodontics and Implantology
Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751