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Zinc supplementation improves glycemic control in overweight type 2 diabetes patients
Iran: Zinc supplementation in overweight patients with type 2 diabetes mellitus (T2DM) may help in glycemic control by enhancing total antioxidant capacity, a recent study published in Postgraduate Medical Journal has shown.Zinc supplementation
"These data and our previous data indicate that the control in the glycaemic condition in these patients is correlated with the antioxidative/oxidative balance following 50 mg zinc supplementation for weight weeks," the researchers wrote. "Under these circumstances, the glycemic and clinical indices, including insulin, fasting blood glucose, homeostasis model of assessment-insulin resistance, and haemoglobin A1c were controlled."
Zinc is a nutrient naturally occurring in many foods such as meat, beans, and fish. It helps support various body functions, most notably helping the immune system due to its antioxidant properties. It can also be taken as a dietary supplement that people can have in addition to dietary sources to ensure an adequate nutrient intake.
Previous studies show that the recommended zinc dose may not be adequate for controlling pathological conditions such as type 2 diabetes. Mohammad Reza Nazem, Tarbiat Modares University, Tehran, Iran, and colleagues aimed to assess the effects of zinc supplementation on the oxidative status in overweight type 2 diabetes patients. In addition, they also determined routine glycaemic parameters and compared them in patients treated with zinc or placebo in a randomised, double-blind, placebo-controlled trial.
The study included 70 patients with type 2 diabetes. They were divided into two groups for 50 mg zinc gluconate supplementation (zinc group, n=35) or placebo (placebo group; n=35) per day for eight weeks. Blood samples were collected for all individuals in the zinc group and control for the analysis.
The study revealed the following findings:
- Zinc supplementation to patients with type 2 diabetes for eight weeks significantly inhibited serum levels of lipid peroxidation (25%), total oxidant status levels (25%), and nitrotyrosine (30%).
- The total antioxidant capacity was significantly increased (16%) after zinc intake by type 2 diabetes patients.
"The control in the blood sugar condition in overweight patients with type 2 diabetes is correlated with the antioxidative/oxidative balance following 50 mg zinc supplementation for eight weeks," the researchers concluded.
Reference:
Nazem, M. R., Asadi, M., Adelipour, M., Jabbari, N., & Allameh, A. Zinc supplementation ameliorates type 2 diabetes markers through the enhancement of total antioxidant capacity in overweight patients. Postgraduate Medical Journal. https://doi.org/10.1136/postgradmedj-2021-140878
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751