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Evergreen Talk Series: Clinical Considerations for Linagliptin and its combinations with Metformin, Dapagliflozin - Video

Published On 2024-01-02T11:00:01+05:30  |  Updated On 11 Jan 2024 2:57 PM IST
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Overview

Presenting the Evergreen Talk Series featuring Dr. Brij Mohan Makkar, a Senior Diabetologist and Obesity Specialist from Delhi, Dr Sameer I. Dani, an Interventional Cardiologist from Ahmedabad, and Dr. Tukaram Jamale, a Nephrologist and Kidney Transplant Physician who serves as the Head of the Department at KEM Hospital Mumbai. They provide their insights on the use of Linagliptin, Dapagliflozin, and Metformin for diabetic patients.

Bringing viewpoints from the different specialities of Diabetology, Cardiology and Nephrology they share the Clinical Considerations for Linagliptin and its combinations with Metformin and Dapagliflozin


Dr Brij Mohan Makkar: The advantage of having a Fixed-Dose Combination (FDC) is improved compliance, making therapy more effective. Now, when it comes to the use of combinations, I think there is hardly any scenario where I do not use the combination of Linagliptin and Metformin. In my practice, I am more aggressive and frequently use a combination of Metformin, DPP4, and SGLT2 inhibitors to begin with. The only scenarios where I would not use this combination are if there is any hypersensitivity to any of these molecules or if the patient is very elderly and frail, in which case, I refrain from using the initial combination of Metformin, DPP4, and SGLT2 inhibitors


Dr Sameer I Dani: All established CVD patients, particularly those with heart failure or those at high risk of developing HF, I would prefer Linagliptin with Dapagliflozin. This combination is suitable for heart failure patients across all stages of CKD. I would prefer Linagliptin with Metformin or Linagliptin monotherapy in all other cases of diabetes who are at very high risk of developing ASCVD or where dapagliflozin is not very useful, very thin patient or patient with high risk of established recurrent genital UTI.


Dr Tukaram Jamale: Unlike our previous thinking, where we used to stop Metformin as soon as serum creatinine goes above 1.4 or 1.5, that wisdom no longer holds true today. Currently, we consider it safe, provided that kidney function is stable, at least until the EGFR is less than 30 mL per minute. And, of course, if the patient is on a DPP4 inhibitor, it can be very well combined with Metformin, reducing the pill burden

Speakers

Dr. Brij Mohan Makkar

Dr. Brij Mohan Makkar, MBBS, MD, FIAMS, is a leading Senior Diabetologist & Obesity Specialist in the country. Dr. Makkar completed his post-graduation in internal medicine from Maulana Azad Medical College, New Delhi. His areas of interest are Diabetes, Obesity and metabolic syndrome.

Dr Sameer I. Dani

Dr. Sameer I Dani MBBS, MD (General Medicine), DM (Cardiology) is a renowned Intervention Cardiologist. He is associated with Apollo CVHF Heart Institute, Ahmedabad as Chief Cardiologist.

Dr Tukaram Jamale

Dr Tukaram Jamale MBBS, MD (Medicine), DM (Nephrology) is a Kidney and Transplantation Specialist and Nephrologist/Renal Specialist. Dr Tukaram is working as HOD at KEM hospital, Mumbai.

MD Brand Connect

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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