Evergreen Talk Series: Clinical Benefits of Linagliptin and Dapagliflozin Combination in Type 2 Diabetes Management
Presenting the Evergreen Talk Series featuring Dr. Brij Mohan Makkar, a Senior Diabetologist and Obesity Specialist from Delhi, Dr. Sameer I. Dani, an Interventional Cardiologist from Ahmedabad, and Dr. Tukaram Jamale, a Nephrologist and Kidney Transplant Physician who serves as the Head of the Department at KEM Hospital Mumbai. They provide their insights on the use of Linagliptin, Dapagliflozin, and Metformin for diabetic patients.
Bringing viewpoints from the different specialities of Diabetology, Cardiology and Nephrology they share the clinical benefits of the Linagliptin and Dapagliflozin combination in Type 2 Diabetes management.
Dr Brij Mohan Makkar: Both are important OADs; the mechanisms that contribute to the development of hyperglycemia and increased blood glucose level that are targeted by these two molecules are actually different mechanisms, so they have good complementary action. They provide a good synergy as far as the treatment of diabetes is concerned. Both these drugs help control glycemia, and at the same time, they reduce the risk of complications; that is why they provide a very good synergy, and they can be an Evergreen combination for treating people with T2DM.
Dr Sameer I Dani: For Asians and Indians, especially those who are considered thin fat people as far as the CV risk category goes, these drugs in combination will probably offer maximum CV benefits to diabetic patients. It is not only the intensive glycemic control that is important; it is very important to show that you have improved cardiovascular outcomes in a diabetic patient.
Dr Tukaram Jamale: With regards to kidney protection due to diabetic kidney disease, dapagliflozin is best supported by the evidence both in patients with diabetes and even in non-diabetic chronic kidney disease. Linagliptin can offer the best of the two worlds. One is the Glycemic control, and the other is organ protection. So, this would definitely make a case for this combination to be used.