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Low FODMAP diet beneficial for GI symptoms in patients with celiac disease: Study
Low fermentable oligo-, di-, monosaccharides and polyols (FODMAP) in addition to a strict gluten-free diet, diet beneficial for GI symptoms in patients with celiac disease, according to a recent study published in the Clinical Gastroenterology and Hepatology.
A gluten-free diet usually leads to mucosal remission in celiac disease, but persistent symptoms are common. A Low FODMAP diet is an established treatment for irritable bowel syndrome (IBS).
A group of researchers have assessed the efficacy of a moderately low FODMAP diet on persistent symptoms in treated celiac patients.
A randomized controlled trial was performed 2018-2019 in 70 adults with biopsy-proven celiac disease. Inclusion criteria: persistent gastrointestinal symptoms defined by Gastrointestinal Symptom Rating Scale-IBS version (GSRS-IBS) score≥ 30, gluten-free diet adherence≥ 12 months, serological and mucosal remission.
Participants were randomized to a low FODMAP-gluten-free diet (intervention) or the usual 58 gluten-free diets (control). GSRS-IBS was recorded at baseline and weeks 1-4, and 59 Celiac Symptom Index (CSI) at baseline and week 4. Statistics: marginal models for repeated data and analyzes of covariance.
The Results of the study are:
The researchers included 34 participants in the intervention and 36 in the control group. Time development of GSRS-IBS total scores differed significantly between the groups, evident after one week (mean difference (95% CI) intervention versus control (-8.2 (-11.5,-5.0)) and persisting through week 4 (-10.8 (-14.8,-6.8)). Moreover, significantly lower scores were found for the dimensions pain, bloating, diarrhoea and satiety (Pinteraction≤ 0.04), but not constipation (Pinteraction=0.43). FODMAP intake during the intervention was moderately low (mean 8.1 g/day (95% CI 6.7, 9.3)). CSI was significantly lower in the intervention group at week 4 (mean differences (95% CIs): -5.8 (-9.6,-2.0).
Thus, the researchers concluded that a short-term moderately low FODMAP diet significantly reduced 71 gastrointestinal symptoms and increased celiac disease-specific health, and should be considered for the management of persistent symptoms in celiac disease.
Reference:
A low FODMAP diet reduces symptoms in treated celiac patients 2 with ongoing symptoms – a randomized controlled trial by Frida van Megen et al. published in the Clinical Gastroenterology and Hepatology.
https://www.cghjournal.org/article/S1542-3565%2822%2900034-9/pdf
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751