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Higher vitamin D intake may reduce risk of colorectal cancer: Study
Higher intake of total vitamin D is associated with decreased risks of early-onset colorectal cancer and precursors, suggests a study published in Gastroenterology.
The role of Vitamin D has been greatly discussed in colorectal cancer (CRC) pathogenesis; however, it is unclear whether the total vitamin D intake is linked with early-onset colorectal cancer.
A study was conducted by a group of researchers from Harvard T.H. Chan School of Public Health, U.S.A, to investigate the association of increased dietary intake of total Vitamin D and its association with early-onset colorectal cancer and precursors diagnosed before age 50.
The researchers studied the potential linkage between total vitamin D intake and risks of early-onset colorectal cancer and precursors among a cohort of young women recruited in the Nurses' Health Study II.
In total, they recorded 111 incident cases of early-onset colorectal cancer during 1,250,560 person-years of follow-up (1991 to 2015).
They predicted the multivariable-adjusted hazard ratio (HR) and 95% confidence interval (CI) for early-onset colorectal cancer by using the Cox proportional hazards model.
Further, Multivariable-adjusted odds ratio (OR) and 95% CI for early-onset conventional adenoma and serrated polyp were predicted using a logistic regression model.
The results of the study are as follows:
· Higher total vitamin D intake was significantly associated with a reduced risk of early-onset colorectal cancer.
· While the inverse association was prominent, it appeared more evident for dietary sources of vitamin D.
· In case of colorectal cancer precursors, the Odds ratio per 400 IU/day increase were 0.76 (95% CI, 0.65-0.88) for conventional adenoma (n = 1,439) and 0.85 (95% CI, 0.75-0.97) for serrated polyp (n = 1,878).
The researchers concluded that higher total vitamin D intake was actually associated with decreased risks of early-onset CRC and precursors.
Reference:
A study titled, "Total vitamin D intake and risks of early-onset colorectal cancer and precursors" by Kim H published in Gastroenterology.
DOI: https://doi.org/10.1053/j.gastro.2021.07.002
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751