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  • HOMA-IR Identified as...

HOMA-IR Identified as Independent Predictor of Liver Fibrosis in MAFLD, suggests study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-09-04T08:15:31+05:30  |  Updated On 4 Sept 2025 12:35 PM IST
HOMA-IR Identified as Independent Predictor of Liver Fibrosis in MAFLD, suggests study
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According to a recent study published in Scientific Reports insulin resistance as assessed by the homeostatic model assessment for insulin resistance (HOMA-IR) has been identified as an independent predictor of substantial liver fibrosis in metabolic dysfunction-associated fatty liver disease (MAFLD) patients. This observation underscores the significance of adding HOMA-IR to the criteria recently suggested metabolic dysfunction-associated steatotic liver disease (MASLD) eliminating HOMA-IR as a criterion for metabolic dysregulation. In this analysis, HOMA-IR was robustly linked with severe stages of liver fibrosis, regardless of diabetes status or body mass index (BMI). The study was conducted by Yasser F. and colleagues.

This was a cross-sectional multicenter study of 364 patients diagnosed with MAFLD. Multiple logistic regression analysis was employed to study the correlation between HOMA-IR and significant fibrosis, i.e., F ≥ 2. Fibrosis was assessed with two non-invasive techniques: the FIB-4 score and LSM. Correlation between rising insulin resistance and risk of fibrosis was correlated in different patient populations, viz., diabetic, non-diabetic, lean, and non-lean populations.

Results

• The analysis showed that every unit increase in HOMA-IR equated to a 16% greater probability of important fibrosis when measured by non-invasive scoring, regardless of BMI and diabetes status.

• In non-diabetic patients, HOMA-IR was independently linked with important fibrosis (OR: 1.14, 95% CI: 1.07–1.21, P < 0.001).

• In diabetic patients, the association was also present (OR: 1.03, 95% CI: 1.00–1.06, P = 0.03).

• In lean patients, HOMA-IR predicted fibrosis with an odds ratio of 1.06 (95% CI: 1.01–1.12, P = 0.03).

• In non-lean patients, the association remained strong (OR: 1.04, 95% CI: 1.02–1.07, P < 0.001).

• Overall, HOMA-IR consistently demonstrated predictive value for significant liver fibrosis across all subgroups.

The research proved that HOMA-IR is an independent predictor of severe fibrosis in MAFLD patients regardless of diabetes or BMI status. Adding HOMA-IR to the diagnostic and prognostic assessment of fatty liver patients would enhance early detection and risk stratification. Researchers underscored that HOMA-IR must be acknowledged as a vital disease progression marker and added to clinical practice.

Reference:

Fouad Y, Pan Z, Nafady S, et al. HOMA-IR, an independent predictor of advanced liver fibrosis in metabolic-dysfunction associated fatty liver disease: a cross-sectional study in Egyptian patients. Sci Rep. 2025;15(1):31098. Published 2025 Aug 24. doi:10.1038/s41598-025-15425-7

Scientific ReportsMAFLDMASLDHOMA-IRinsulin resistancefibrosisnon-invasive markersFIB-4liver stiffness measurementdiabetesobesity
Source : Scientific Reports
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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