Neuromodulators and Prokinetics Combo Effective for treatment of Gastroparesis

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-20T01:30:39+05:30 | Updated On 20 Nov 2023 1:30 AM IST

A recent study sheds light on the limited effectiveness of traditional prokinetic therapies for gastroparesis, a condition characterized by delayed stomach emptying. The findings were published in the Clinical Gastroenterology and Hepatology.

The comprehensive research encompassed 129 patients with gastroparesis symptoms, and focused into alternative approaches such as gastroparesis diets and neuromodulators, either in isolation or combination. The study employed wireless motility capsule gastric emptying time (GET) and gastric emptying scintigraphy (GES) to assess patient responses to various therapies over a period of 6 months. Notably, the Gastroparesis Cardinal Symptom Index (GCSI) served as a key metric to measure symptom changes.

The findings underscored that prokinetics, when used as a standalone therapy, demonstrated limited efficacy in reducing symptoms, emphasizing the need for alternative or complementary treatments. In contrast, neuromodulators, administered alone, exhibited promising results by decreasing GCSI scores and alleviating individual symptoms, excluding nausea/vomiting.

This study revealed that combining prokinetics with gastroparesis diets or neuromodulators yielded more favorable outcomes. This suggests that a multi-faceted treatment approach might offer enhanced relief for patients grappling with gastroparesis symptoms.

Multivariate analyses, factoring in gastric emptying and other variables, reinforced the conclusions of study. Notably, patients with non-delayed gastric emptying responded more positively to neuromodulators as a solo therapy, emphasizing the importance of tailoring treatments to individual patient profiles.

This approach opens avenues for reevaluating therapeutic strategies for gastroparesis. While prokinetics alone may offer limited relief, combining them with complementary therapies like neuromodulators or dietary adjustments presents a more promising avenue for managing this challenging condition.

Reference:

Hasler, W. L., Lee, A. A., Moshiree, B., Surjanhata, B. C., Rao, S., Parkman, H. P., Nguyen, L. A., Sarosiek, I., Wo, J. M., Schulman, M. I., McCallum, R. W., & Kuo, B. (2023). BENEFITS OF PROKINETICS, GASTROPARESIS DIET, OR NEUROMODULATORS ALONE OR IN COMBINATION FOR SYMPTOMS OF GASTROPARESIS. In Clinical Gastroenterology and Hepatology. Elsevier BV. https://doi.org/10.1016/j.cgh.2023.10.014

Source : Clinical Gastroenterology and Hepatology

Jacinthlyn Sylvia

Neuroscience Masters graduate

Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751