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Severe vitamin D deficiency linked to fatty liver: Study
Blida, Algeria: Results from a recent study have revealed a positive association between severe vitamin D deficiency and non-alcoholic fatty liver disease (NAFLD). The study appears in the Journal of Diabetes & Metabolic Disorders. Also, the authors quantified an an excess risk in women combining both metabolic syndrome (MS) and severe vitamin D deficiency.
NALFD is a very common liver disorder and indicates a group of condition wherein there is accumulation of excess fat in the liver of people who drink little or no alcohol. A non serious condition called fatty liver is the most common form of NALFD. Previous studies on the association between hypovitaminosis D and NAFLD have yielded conflicting results. Salam Bennouar, University Hospital center of Blida, Blida, Algeria, and colleagues, therefore, aimed to explore the individual and combined effect of hypovitaminosis D and MS on NAFLD in a cross-sectional study.
The study included 874 participants. The researchers used a sequential competitive immuno-fluoro-assay method for assessing 25(OH)D, and Fatty Liver Index (FLI) was used for NAFLD screening. The association between vitamin D status, MS and NAFLD was investigated using binary logistic regression and additive interaction.
Following were the study's key findings:
- Severe vitamin D deficiency was found to be positively related to NAFLD, women were at higher risk versus men (OR = 6.4 vs. OR = 5.8).
- In men, this association was partially masked by obesity.
- The additive interaction with MS was significant in women but not in men, the relative excess risk due to interaction was of 7.2, the attributable proportion due to the combined effect was of 0.6.
- The interaction mechanism is synergistic; the synergy index: was of 2.9.
"We found a positive association between severe vitamin D deficiency and NAFLD," wrote the authors. "Moreover, an excess risk in women combining both MS and severe vitamin D deficiency was quantified."
Reference:
Bennouar, S., Cherif, A.B., Kessira, A. et al. Association and interaction between vitamin D level and metabolic syndrome for non-alcoholic fatty liver disease. J Diabetes Metab Disord 20, 1309–1317 (2021). https://doi.org/10.1007/s40200-021-00857-5
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751