Bacampicillin

Bacampicillin belongs to the pharmacological class of Beta-Lactam Antibiotics.

Bacampicillin had been approved to relieve symptoms and also for the treatment and maintenance of infections due to Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Meningitis, Otitis media, Paratyphoid fever, Perinatal streptococcal infections, Peritonitis, Pneumonia, Septicaemia, Typhoid fever, Urinary tract, Uncomplicated Gonorrhea.

Bacampicillin is rapidly absorbed in the Gastrointestinal tract. Bacampicillin is hydrolyzed in intestinal walls and plasma to ampicillin. About 75% of a dose of Bacampicillin is excreted in the urine within 8 hr.

The common side effects involving the use of Bacampicillin are fever, angioedema, joint pains, phlebitis, irritation at the site of injection, vomiting, headache, diarrhea, headache, upset stomach, etc.

Bacampicillin is available in the form of Tablets.

Bacampicillin belongs to the pharmacological class of Beta-Lactam Antibiotics.

Bacampicillin acts by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Bacampicillin is also said to inhibit the third and last stage of bacterial cell wall synthesis. The cell lysis is then mediated by the bacterial cell wall autolytic enzymes example autolysins. It is possible that Bacampicillin interferes with an autolysin inhibitor.

Bacampicillin had been approved to relieve symptoms and also for the treatment and maintenance of infections due to Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Meningitis, Otitis media, Paratyphoid fever, Perinatal streptococcal infections, Peritonitis, Pneumonia, Septicaemia, Typhoid fever, Urinary tract, Uncomplicated Gonorrhea.

Bacampicillin was available in the form of Tablets.

Bacampicillin was being used in the following treatment:

• Biliary tract infections
• Bronchitis
• Endocarditis
• Gastroenteritis
• Listeriosis
• Meningitis
• Otitis media
• Paratyphoid fever
• Perinatal streptococcal infections
• Peritonitis
• Pneumonia
• Septicaemia
• Typhoid fever
• Urinary tract infections
• Uncomplicated gonorrhea

Bacampicillin has been indicated to help to relieve symptoms as well as also for the treatment and maintenance of infections due to Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Meningitis, Otitis media, Paratyphoid fever, Perinatal streptococcal infections, Peritonitis, Pneumonia, Septicaemia, Typhoid fever, Urinary tract, Uncomplicated Gonorrhea.

Bacampicillin was approved for use in the following clinical indications:

• Biliary tract infections
• Bronchitis
• Endocarditis
• Gastroenteritis
• Listeriosis
• Meningitis
• Otitis media
• Paratyphoid fever
• Perinatal streptococcal infections
• Peritonitis
• Pneumonia
• Septicaemia
• Typhoid fever
• Urinary tract infections
• Uncomplicated gonorrhea

Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Meningitis, Otitis media, Paratyphoid fever, Perinatal streptococcal infections, Peritonitis, Pneumonia, Septicaemia, Typhoid fever, Urinary tract infections

Adult: 400-800 mg bid-tid.

Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Uncomplicated gonorrhea

Adult: 1.6 g with 1 g probenecid as a single dose.

Bacampicillin was available in the form of, 400 mg, 800 mg, tablets

Avoid high-acid foods like citrus fruits and juices like oranges, grapefruit, soda, and chocolates.

Alcohol intake might lead to nausea, vomiting, and headache

Multivitamins and antacids contain minerals, primarily magnesium, calcium, aluminum, iron, or zinc, which bind to the antibiotic and refrain it from working. Spacing them at least for 2 hours after Bacampicillin administration is recommended.

Bacampicillin may is contraindicated under the following conditions:

• Patients with known hypersensitivity to Penicillin and cephalosporins.

The adverse reactions related to Bacampicillin can be categorized as follows:

• Neutropenia
• Thrombocytopenia
• CNS toxicity, including convulsions
• Diarrhea
• Urticaria
• Fever
• Joint pains
• Rashes
• Angioedema
• Serum sickness-like reactions
• Hemolytic anemia
• Interstitial nephritis
• Antibiotic-associated colitis
• Nausea
• Vomiting
• Pseudomembranous colitis

The clinically relevant drug interactions of Bacampicillin are briefly summarized here:

• Simultaneous administration of the drug probenecid reduces the excretion of penicillins and hence increases the blood level of the antibiotic.
• The bactericidal effect of penicillins can be hindered by concurrent administration of products with bacteriostatic effects, for instance, erythromycin and tetracyclines.

The following are the side effects involving Bacampicillin :

• Pregnancy

Category B

The clinical data on pregnant women, which is more than 1000 pregnancy outcomes, indicates that there is no malformation nor feto/neonatal toxicity of Bacampicillin. Bacampicillin can be used in pregnancy if clinically needed.

Physicians should be knowledgeable as well as vigilant about the treatment and identification of over dosage of Bacampicillin.

There is no experience of over dosage with Bacampicillin (Bacampicillin hydrochloride) tablets. However, excessive doses of Bacampicillin are likely to induce nausea, vomiting, abdominal pain, and diarrhea.

Pharmacodynamics

Bacampicillin is said to be a prodrug of ampicillin and is microbiologically inactive.

Pharmacokinetics

• Absorption: Rapidly absorbed in the Gastrointestinal tract.

• Metabolism: Hydrolyzed in intestinal walls and plasma to ampicillin.

• Excretion: About 75% of a dose is excreted in the urine within 8 hrs. as ampicillin.

• https://www.mims.com/malaysia/drug/info/bacampicillin?mtype=generic
• https://en.wikipedia.org/wiki/Bacampicillin
• https://www.drugs.com/mtm/bacampicillin.html
• https://go.drugbank.com/drugs/DB01602
• https://pubchem.ncbi.nlm.nih.gov/compound/Bacampicillin
• https://drugs.ncats.io/drug/8GM2J22278
• http://www.antimicrobe.org/drugpopup/bacampicillin.htm