Allopathy
Prescription Required
DCGI (Drugs Controller General of India)
Schedule H
Carbenoxolone is a Triterpenoids belonging to Antacids / Antiulcer agent.
Carbenoxolone is a drug used to symptomatically treat lip sores and mouth ulcers.
Carbenoxolone is Absorbed in the GI tract, mainly from the stomach.Carbenoxoloneis Highly bound to plasma proteins.Carbenoxolone Mainly excreted in the faeces via the bile.
Carbenoxolone shows side effects like Sodium and water retention, hypokalaemia.
Carbenoxolone is available in the form of Oral tablet and Gel.
Carbenoxolone is available in India, US, Singapore, Malaysia, China, Russia and Japan.
Carbenoxolone belongs to the Antacids / Antiulcer agent acts as a Triterpenoids.
Carbenoxolone is a synthetic derivative of glycyrrhizinic acid (a constituent of liquorice). It acts by protecting the mucosal barrier from acid-pepsin attack and increasing mucosal mucin production.
The Data of Onset, Duration of action and Tmax of Carbenoxolone is not clinically established.
Carbenoxolone is available in the form of Oral tablet and Gel.
Carbenoxolone tablet is taken orally, usually three time daily while Gel is applied cutaneous usually four times daily.
Carbenoxolone is used for the treatment of peptic, esophageal, and oral ulceration and inflammation.
Carbenoxolone is a Triterpenoids belonging to Antacids / Antiulcer agent.
Carbenoxolone may act by affecting both the proliferative activity of gastric epithelium and the differentiation of the epithelial cells to produce mucus.
Carbenoxolone is approved for use in the following clinical indications
- Gastro-oesophageal reflux disease
- Mouth ulceration
- Gastro-oesophageal reflux disease
Adult Oral Dose: 20 mg three times daily.
- Mouth ulceration
AdultTopical/Cutaneous Dose: Apply 2% gel 4 times daily.
Carbenoxolone is available in various strengths as 0.5mg.
Carbenoxolone is available in the form of Oral tablet and Gel.
Carbenoxolone is contraindicated in patients with
- Hypokalaemia
- cardiac failure and in those receiving cardiac glycosides.
- Pregnancy, elderly, child <3 yrs patients.
- Common
Sodium and water retention, hypokalemia.
- Antagonism with amiloride and spironolactone.
- Exacerbates hypokalaemia associated with diuretics.
- Risk of toxicity with digitalis glycosides.
The common side effects of Carbenoxolone include the following
- Common side effects
Sodium and water retention, hypokalemia.
- Pregnancy
Pregnancy Category B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
- Pharmacodynamic
Information not available.
- Pharmacokinetics
Absorption
Carbenoxolone is Absorbed in the GI tract, mainly from the stomach.
Distribution
Carbenoxolone is Highly bound to plasma proteins.
Metabolism and Excretion
Carbenoxolone Mainly excreted in the faeces via the bile.
- Csonka GW, Tyrrell DA. Treatment of herpes genitalis with carbenoxolone and cicloxolone creams: a double blind placebo controlled clinical trial. Sexually Transmitted Infections. 1984 Jun 1;60(3):178-81.
- Lewis JR. Carbenoxolone sodium in the treatment of peptic ulcer: a review. Jama. 1974 Jul 22;229(4):460-2.
- Reed PI, Davies WA. Controlled trial of a carbenoxolone/alginate antacid combination in reflux oesophagitis. Current Medical Research and Opinion. 1978 Jan 1;5(8):637-44.
- https://www.drugs.com/pregnancy/cabergoline.html
- https://www.mims.com/philippines/drug/info/carbenoxolone?mtype=generic
- https://go.drugbank.com/drugs/DB02329
