Carprofen

Carprofen is Non- Steroidal Anti inflammatory Drugs belonging to Analgesic and Anti inflammatory agents.

Carprofen is used as a pain reliever in the treatment of joint pain and post-surgical pain in dogs.

Carprofen is Rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally.

Carprofen shows common side effects like Depression, dizziness, headache, numbness.

Carprofen is available in Tablet and Capsule.

Carprofen is available in India, Germany, Canada, France, USA.

The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. In an in vitro study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1.

Carprofen is available in the form of tablets and Capsules.

Carprofen is used as a pain reliever in the treatment of joint pain and post-surgical pain in dogs.

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. It is no longer used in the clinical setting, but is approved for use in dogs. Carprofen is non-narcotic and has characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.

Carprofen is approved for use in the following clinical indications

Pain reliever in the treatment of joint pain and post-surgical pain in dogs.

Carprofen is available in the dosage strength of 25 mg, 75 mg and 100 mg.

Carprofen is available in the form of Tablets and Capsules.

• Common Adverse effects:

Depression, dizziness, headache, numbness.

• Less Common Adverse effects:

Anorexia, vomiting, abdominal pain, heartburn, diarrhea, black stool, constipation, dry/sore mouth.

• Rare Adverse effects

Rash, toxic epidermal necrolysis, edema, photosensitivity.

The following drug interactions and/or related problems have been selected on the basis of their potential clinical significance (possible mechanism in parentheses where appropriate)—not necessarily inclusive (» = major clinical significance):

Note: Combinations containing any of the following medications, depending on the amount present, may also interact with this medication.

• Angiotensin-converting enzyme inhibitors (ACE inhibitors) or Furosemide (because ACE inhibitors and furosemide act through the effects of vasodilatory prostaglandins on renal function, NSAIDS may decrease their effectiveness; there is not yet any evidence that this is clinically significant, but blood pressure monitoring is recommended)
• Anti-inflammatory medications, such as Corticosteroids{R-7} Other nonsteroidal anti-inflammatory drugs (concurrent administration with carprofen can increase risk of toxicity, including the risk of gastrointestinal ulceration) Nephrotoxic medications (could exacerbate renal effects of carprofen)
• Phenobarbital (because phenobarbital can cause elevations in liver enzymes, baseline serum chemistries should be established before beginning treatment with any NSAID).

The common side effects of Carprofen include the following :

Renal effects (e.g. glomerular nephritis, interstitial nephritis, renal papillaryz necrosis, nephrotic syndrome, acute renal failure), increase SGOT and SGPT, Drowsiness, headache, dizziness, vertigo, restlessness, Anxiety, insomnia.

Symptoms of NSAID overdose include dizziness and nystagmus.

Oral LD₅₀ in mouse and rat is 282 mg/kg and 149 mg/kg, respectively.

• Pharmacodynamic

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. It is no longer used in the clinical setting, but is approved for use in dogs. Carprofen is non-narcotic and has characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.

• Pharmacokinetics

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/
2. https://reference.medscape.com/drug/colestid-Carprofen -342452
3. https://go.drugbank.com/drugs/DB00375
4. https://www.sciencedirect.com/topics/medicine-and-dentistry/Carprofen
5. https://europepmc.org/article/med/6988203