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OverviewMechanism of ActionHow To UseUsesBenfitsIndicationsMethod of AdministrationDosage StrengthsDosage FormsDietary RestrictionsContraindicationsWarnings and Precautions for usingAdverse ReactionsSide EffectsClinical Pharmacology Authored by Reviewed by References
Cefaloridin

Cefaloridin

Indications, Uses, Dosage, Drugs Interactions, Side effects
Cefaloridin
Drug Related WarningCefaloridin

(It was briefly used for treating infectious disease in 1970. Most commonly used in veterinary practice)

Medicine Type :
Allopathy
Prescription Type:
Prescription Required
Pharmacological Class:
First-generation cephalosporin antibiotics,
Therapy Class:
Antibiotic,

Cefaloridin belongs to the pharmacological class of first-generation semi synthetic cephalosporin antibiotics. Cefaloridin is a cephalosporin C and is a zwitterion at physiological pH.

Cefaloridin is available in the form of Injectables

The common side effects involving the use of Cefaloridin are nausea, vomiting, indigestion, intense abdominal pain ,diarrhea, inflammation at the site of injection.

Cefaloridin belongs to the pharmacological class of first-generation semi-synthetic cephalosporin antibiotics. Cefaloridin is a cephalosporin C and is a zwitterion at physiological pH.

Cefaloridin is a cephalosporin antibiotic, a class of β-lactam antibiotics similar to penicillins, which binds to and inhibits penicillin-binding proteins (PBPs).

Cefaloridin had been approved to relieve symptoms and also for the treatment and maintenance of urinary tract infections, upper respiratory tract infections, staphylococcal and streptococcal infections, and Pneumococcal and pneumonia infections.

Cefaloridin is available in the form of Injectables.

Cefaloridin can be used in the following treatment:

  • Urinary tract infections
  • Upper respiratory tract infections
  • Staphylococcal and Streptococcal infections
  • Pneumococcal and Pneumonia infections

Cefaloridin can help to relieve symptoms and also for the treatment and maintenance of urinary tract infections, upper respiratory tract infections, staphylococcal and streptococcal infections, and Pneumococcal and pneumonia infections.

Cefaloridin is approved for use in the following clinical indications:

  • Urinary tract infections
  • Upper respiratory tract infections
  • Staphylococcal and Streptococcal infections
  • Pneumococcal and Pneumonia infections

Injectables: To be administered by a registered medical practitioner

Detailed information is not available.

Injectables

Avoid high acid foods like citrus fruits and juices like orange and grapefruit, soda and chocolates.

Alcohol intake might lead to nausea,vomiting and headache

Multivitamins and antacids contain minerals primarily magnesium calcium aluminum iron or zinc which binds to the antibiotic and refrain it from working. Spacing them at least for 2 hours after Cefalotin administration is recommended.

Cefaloridin may be contraindicated under the following conditions:

  • Patients with known hypersensitivity to cephalosporins.
  • Previous immediate or severe hypersensitivity reaction to penicillin or to any other beta-lactam medicinal products.

The physician should closely monitor the patients and keep pharmacovigilance as follows:

Cephaloridine should be used with caution in patients with impaired kidney or liver function. Appropriate measures should be taken if secondary infection occurs. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).

Alcohol Warning

Usage of alcohol should be avoided while on Cefaloridin medication, as alcohol can worsen the effects of any underlying disease condition, including conditions such as dizziness, blurred vision, etc.

Food Warning

No sufficient scientific evidence is traceable regarding the use and safety of Cefaloridin in concurrent use with any particular food.

The adverse reactions related to Cefaloridin can be categorized as follows:

  • Pseudomembranous colitis
  • Eosinophilia
  • Abnormalities of blood coagulation
  • Renal damage
  • Vomiting
  • Headache
  • Dizziness
  • Fungal infections of the mouth and vagina
  • Fever

The clinically relevant drug interactions of Cefaloridin is briefly summarized here:

Probenecid prolongs activity by slowing renal tubular excretion.

Potentially Fatal: Furosemide and aminoglycosides prolong T1/2 of cefaloridine and potentiate nephrotoxicity.

The following are the side effects involving Cefaloridin:

● Indigestion

● Nausea

● Diarrhea

● Inflammation at the site of injection

Pharmacodynamics

N.A.

Pharmacokinetics

  • Absorption

Cephaloridine is said to be easily absorbed after intramuscular injection and poorly absorbed from the gastrointestinal tract.

  • Distribution

The minor pathway of elimination is found to be biliary excretion. When the blood serum concentration is found to be 24 µg/ml, the corresponding biliary concentration is 10 µg/ml. In the spinal fluid the concentration of cephaloridine was found to be 6–12% of the concentration in the blood and serum. Cephaloridine is said to be distributed well into the liver, stomach wall, lung and spleen as well as is also found in fresh wounds 1 hour after injection. The concentration in the wound is said to be decrease as the wound age increases. However, the drug is found to be poorly penetrated into the cerebrospinal fluid and is also found in a much smaller amount in the cerebral cortex.

  • Metabolism and excretion

Urine specimens had showed that no other microbiologically active metabolites were present with the exception of cephaloridine and that cephaloridine is excreted unchanged. Renal clearances had been reported to be 146–280 ml/min, a plasma clearance of 167 ml/min/1,73m2 as well as a renal clearance of 125 ml/min/1,73m2. A serum half-life of 1,1-1,5 hour and a volume of distribution of about 16 liters had been reported.

  1. https://www.medindia.net/drugs/medication-side-effects/cephaloridine.htm
  2. htthttps://europepmc.org/article/med/14343692
  3. https://card.mcmaster.ca/ontology/41256
  4. ps://www.drugs.com/sfx/cephalothin-side-effects.html
  5. https://www.tabletwise.net/medicine/cephaloridin
  6. https://www.medindia.net/doctors/drug_information/cephaloridine.htm
  7. https://go.drugbank.com/drugs/DB09008
  8. https://www.druginfosys.com//drug.aspx?drugCode=149&type=1
  9. https://pubchem.ncbi.nlm.nih.gov/compound/Cephaloridine
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Sonali R Muralidhar
I am Sonali R Muralidhar currently residing at Madurai.I have completed my Master’s in Pharmacy with my core subject as Pharmaceutics. I am interested in Pharmaceutical research , medical content writing, Biopharmaceutics , regulatory affairs , novel drug delivery, targeted drug delivery.
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Dr JUHI SINGLA
Dr JUHI SINGLA has completed her MBBS from Era’s Lucknow Medical college and done MD pharmacology from SGT UNIVERSITY Gurgaon. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
Published on: 4 March 2023 5:47 PM GMT
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