Cilomilast

Cilomilast belongs to the pharmacological class of Phosphodiesterase-4 inhibitors. Cilomilast appears to have anti-inflammatory effects.

Cilomilast was being studied for the treatment as well as for relieving the symptoms and maintenance of episodes of asthma and Chronic obstructive pulmonary disease.

The common side effects associated with Cilomilast are hives, itching, and swelling. Joint pain, hoarseness, irritation, redness of the skin, tightness of the chest, troubled breathing, etc.

Cilomilast belongs to the pharmacological class of Phosphodiesterase-4 inhibitors. Cilomilast appears to have anti-inflammatory effects.

Cilomilast shows high selectivity for cAMP-specific PDE4, which is said to be an isoenzyme which predominates in pro-inflammatory and immune cells and that is ten-fold more selective for PDE4D than for PDE4A, -B, or -C. In vitro, cilomilast is said to suppress the activity of several pro-inflammatory and immune cells that have been found to be implicated in the pathogenesis of COPD and asthma. Moreover, it is said to be highly active in animal models of these diseases. Cilomilast had shown to exert potent anti-inflammatory effects both in vitro and in vivo.

Cilomilast was being studied for the treatment as well as relieving the symptoms and maintenance of episodes of asthma and Chronic obstructive pulmonary disease.

Cilomilast can be used in the treatment of:

• Asthma
• Chronic Obstructive Pulmonary Disease

Cilomilast was being studied in the following clinical indications:

• Asthma
• Chronic Obstructive Pulmonary Disease

Maintaining health and cessation of smoking are a must.

Caffeine should be limited to use or avoided as it may lead to the risk of nervousness, rapid heartbeat, nausea, palpitations, etc.

Patients with an underlying liver disorder or liver dysfunction must avoid drinking alcohol.

A diet containing food with high sugar content and carbohydrates should be restricted. This includes pies, cakes, honey, cookies, jams, candies, chips, and bread. It is also advised to reduce or limit the intake of cholesterol and saturated fat and instead choose poultry, lean meat, or fish.

The dietary restrictions need to be individualized as per the patient's requirements.

Cilomilast mIGHT be contraindicated under the following conditions:

• Hypersensitivity to the ingredients of the medication

No formal drug interaction studies had been conducted.

1. https://go.drugbank.com/drugs/DB03849
2. https://adisinsight.springer.com/drugs/800004641
3. https://www.pharmacodia.com/yaodu/html/v1/chemicals/d1d88beb304d082e37a8b584ff39c03d.html
4. https://www.clinicaltrialsarena.com/projects/ariflo/