Dexibuprofen

Dexibuprofen is Non- Steroidal Anti inflammatory Drug belonging to Analgesic and Anti-inflammatory agents.

Dexibuprofen is used as pain reliever in the treatment of Osteoarthritis, Dysmenorrhoea and mild to moderate pain.

Dexibuprofen is Well-absorbed mainly from the small intestine with Plasma protein binding: Approx 99% and gets metabolised in the liver via hydroxylation and carboxylation to inactive metabolites, which gets excreted Via urine (90%) and faeces—elimination half-life: 1.8-3.5 hours.

The onset of action of Dexibuprofen was within 1 hour.

The Tmax of Dexibuprofen was within 2 hours.

Dexibuprofen shows common side effects like Renal effects (e.g. glomerular nephritis, interstitial nephritis, renal papillary necrosis, nephrotic syndrome, acute renal failure), increase SGOT and SGPT, Drowsiness, headache, dizziness, vertigo, restlessness, Anxiety, insomnia.

Dexibuprofen is available in Tablets and capsules.

Dexibuprofen is available in India, Germany, Canada, France, USA.

Dexibuprofen is a non-steroidal anti-inflammatory drug (NSAID). The drug is administered mainly for the pain-relieving properties of this medicine, especially in cases of severe arthritis, muscular strains, sprains and other painful injuries. The treatment may also be used to provide relief from menstrual pain, abdominal cramps, and even dental aches.

Dexibuprofen is available in the form of tablets and Capsules.

Dexibuprofen is used as pain reliever in the treatment of Osteoarthritis, Dysmenorrhea, and mild to moderate pain.

Dexibuprofen is the S(+)-enantiomer of ibuprofen, a non-selective NSAID. Its mechanism of action may be due to the inhibition of prostaglandin synthesis resulting in reduced pain, inflammation and fever.

Dexibuprofen is approved for use in the following clinical indications

Osteoarthritis, Dysmenorrhea, and mild to moderate pain.

Oral

Osteoarthritis, Dysmenorrhoea

Adult: 600-900 mg daily in 2-3 divided doses, may be increased up to Max 1,200 mg daily if necessary—Max: 400 mg/dose.

Elderly: Use lowest effective dose.

Oral

Mild to moderate pain

Adult: 600 mg daily in 2-3 divided doses, may be increased up to Max 1,200 mg daily if necessary—Max: 400 mg/dose.

Elderly: Use the lowest effective dose.

Dexibuprofen is available in the dosage strength of 200 mg, 300 mg, 400 mg.

Dexibuprofen is available in the form of Tablets and Capsules.

Dexibuprofen is contraindicated in patients with:

Hypersensitivity to NSAIDs. Active or history of recurrent peptic ulcer/hemorrhage, history of gastrointestinal bleeding or perforation associated with previous NSAID therapy; cerebrovascular bleeding or other active bleedings, active Crohn’s disease or ulcerative colitis; severe heart failure. Severe renal (GFR <30 mL/min) and hepatic impairment. Pregnancy (3rd trimester). Concomitant use with NSAIDs including COX2-selective inhibitors.

• Common Adverse effects:

Renal effects (e.g. glomerular nephritis, interstitial nephritis, renal papillary necrosis, nephrotic syndrome, acute renal failure), increase SGOT and SGPT, Drowsiness, headache, dizziness, vertigo, restlessness, Anxiety, insomnia.

• Less Common Adverse effects:

Dyspepsia, abdominal pain, diarrhea, nausea, vomiting.

• Rare Adverse effects

Stevens-Johnson syndrome and toxic epidermal necrolysis.

• May increase effect of anticoagulants (e.g. warfarin). May increase plasma levels thus increase risk of toxicity of methotrexate, lithium, digoxin and phenytoin. May reduce antihypertensive effect of β-blockers.
• May increase risk of nephrotoxicity with immunosuppressants (e.g. ciclosporin, tacrolimus, sirolimus) and aminoglycoside antibiotics.
• Increased risk of gastrointestinal ulceration and bleeding with corticosteroids, antiplatelets and selective serotonin reupdate inhibitors.
• Reduced effect with CYP2C8 and CYP2C9 inducing agents (e.g. phenytoin, phenobarbital, rifampicin).
• Potentially Fatal: Increased risk of gastrointestinal bleeding, ulceration or perforation, and renal failure with NSAIDs including selective COX-2 inhibitors.

The common side effects of Dexibuprofen include the following :

Renal effects (e.g. glomerular nephritis, interstitial nephritis, renal papillary necrosis, nephrotic syndrome, acute renal failure), increase SGOT and SGPT, Drowsiness, headache, dizziness, vertigo, restlessness, Anxiety, insomnia.

Symptoms: Mild symptoms include abdominal pain, nausea, vomiting, lethargy, drowsiness, headache, nystagmus, tinnitus and ataxia. Rarely, moderate or severe symptoms such as gastrointestinal bleeding, hypotension, hypothermia, metabolic acidosis, seizures, impaired kidney function, coma, adult respiratory distress syndrome and transient episodes of apnoea (young children following large ingestions).

Management: Symptomatic treatment. Small ingested amounts (<50 mg/kg) may be diluted water to reduce gastrointestinal upset. Consider emesis to empty stomach within 60 minutes of ingestion.

• Pharmacodynamic

Dexibuprofen is the S(+)-enantiomer of ibuprofen, a non-selective NSAID. Its mechanism of action may be due to inhibition of prostaglandin synthesis resulting to reduced pain, inflammation and fever.

• Pharmacokinetics

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/
2. https://reference.medscape.com/drug/colestid-Dexibuprofen -342452
3. https://go.drugbank.com/drugs/DB00375
4. https://www.sciencedirect.com/topics/medicine-and-dentistry/Dexibuprofen
5. https://europepmc.org/article/med/6988203