Droxicam

Droxicam is Non- Steroidal Anti inflammatory Drugs belonging to Analgesic and Anti inflammatory agents.

Droxicam is used in the treatment of inflammation and rheumatoid arthritis.

Droxicam is Bioavailability equivalent to Piroxicam which is thought to be completely absorbed in humans based on data from rabbits

The Tmax of Droxicam was within 7 hours.

Droxicam shows common side effects like Oedema, HTN, cardiac failure, nausea, epigastric pain, diarrhea, indigestion, heartburn, flatulence, abdominal pain, constipation, vomiting, ulcerative stomatitis, dyspepsia, haematemesis, melaena, rectal bleeding, exacerbation of colitis, vasculitis, headaches

Droxicam is available in India, Germany, Canada, France, USA.

Droxicam is a nonsteroidal anti-inflammatory drug that is a pro-drug of piroxicam. The mechanism of action of droxicam, as well as that of piroxicam, is that of inhibition of prostaglandin biosynthesis. Droxicam acts by inhibition of PGE2. Although it belongs to the oxicam family, it is characterised by being a pro-drug of piroxicam, the molecule undergoing conversion by hydrolysis once dissolved in the digestive tract. Droxicam was used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.

Droxicam is used in the treatment of inflammation and rheumatoid arthritis.

Droxicam possesses considerable analgesic activity, of equal magnitude to that of piroxicam and notably greater than that of acetylsalicylic acid, dipyrone, phenylbutazone and isoxicam. The antipyretic activity of droxicam, studied by means of different tests, has shown itself to be clearly superior to that of acetylsalicylic acid, dipyrone and 4-aminoantipyrine. Droxicam acts as an inhibitor of ex vivo platelet aggregation in the dog. However, owing to hepatotoxicity, droxicam was withdrawn in many countries.

Droxicam is approved for use in the following clinical indications

Inflammation and rheumatoid arthritis.

Droxicam is contraindicated in patients with:

Hypersensitivity (e.g, anaphylactic reaction) to Droxicam or any component of the formulation.

Common Adverse effects:

• Oedema, HTN, cardiac failure, nausea, epigastric pain, diarrhea, indigestion, heartburn, flatulence, abdominal pain, constipation, vomiting, ulcerative stomatitis, dyspepsia, hematemesis, melaena, rectal bleeding, exacerbation of colitis, vasculitis, headaches

Less Common Adverse effects:

• Dizziness, abnormal vision, pyrexia, drowsiness, tinnitus, rash, pruritus, fatigue, depression, insomnia, confusion, paresthesia, tremor, weakness, dyspnea

Rare Adverse effects

• Hepatic function abnormalities, jaundice, urinary frequency, Crohn's disease, photosensitivity, asthma, nephritis, anemia.

The common side effects of Droxicam include the following :

• Oedema, HTN, cardiac failure, nausea, epigastric pain, diarrhea, indigestion, heartburn, flatulence, abdominal pain, constipation, vomiting, ulcerative stomatitis, dyspepsia, hematemesis, melaena, rectal bleeding, exacerbation of colitis, vasculitis, headaches.

• Pharmacodynamic

Droxicam is a nonsteroidal anti-inflammatory drug that is a pro-drug of piroxicam. The mechanism of action of droxicam, as well as that of piroxicam, is that of inhibition of prostaglandin biosynthesis. Droxicam acts by inhibition of PGE2. Although it belongs to the oxicam family, it is characterised by being a pro-drug of piroxicam, the molecule undergoing conversion by hydrolysis once dissolved in the digestive tract. Droxicam was used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis

• Pharmacokinetics

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/
2. https://reference.medscape.com/drug/colestid-Droxicam -342452
3. https://go.drugbank.com/drugs/DB00375
4. https://www.sciencedirect.com/topics/medicine-and-dentistry/Droxicam
5. https://europepmc.org/article/med/6988203