Erythrityl tetranitrate

Erythrityl tetranitrate is an Antintianginal drug belonging to the Vasodilator class.

Erythrityl tetranitrate is used for the prevention of angina.

The common side effects are Low blood pressure, increase or decrease in heart rate, dizziness, and facial flushing.

Erythrityl tetranitrate is available in dosage forms, such as tablets.

Erythrityl tetranitrate is available in Europe, Japan, China, and India.

Erythrityl tetranitrate is converted to an active intermediate compound that activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP), which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Erythrityl tetranitrate is available in the form of dosage forms, such as tablets.

Erythrityl tetranitrate tablets were taken orally with or without food.

Erythrityl tetranitrate is used for the prevention of angina.

Erythrityl tetranitrate is available in various dosage strengths: NA

Erythrityl tetranitrate is available in the form of dosage forms, such as tablets.

Erythrityl tetranitrate is approved for the treatment of Angina pectoris

People at risk for Thromboembolic disease should increase their consumption of fish and poultry while decreasing their intake of fattier meats like beef and pork. Eating fattier meats can cause high cholesterol, which increases the risk of thromboembolic disease.

Diets high in processed foods, such as fast food, and items high in added sugar, like soda and sugary baked goods, have been linked to increased heart disease risk.

Erythrityl tetranitrate may be contraindicated in the following.

Erythrityl tetranitrate is contraindicated in patients allergic to the drug or in those with severe anemia.

• It should not be administered with a drug called riociguat, or phosphodiesterase 5 inhibitors like sildenafil and tadalafil.

• Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo Biloba.
• Ensure consistent Vitamin K intake. Changes in vitamin K intake may impact coagulation.
• Exercise caution with grapefruit products.
• Exercise caution with St. John's Wort.

The adverse reactions related to molecule Erythrityl tetranitrate can be categorized as

• Common Adverse effects: Low blood pressure, increase or decrease in heart rate, dizziness, facial flushing.
• Less Common Adverse effects: Headache, apprehension, weakness, rashes, Methemoglobinemia.

Pharmacodynamics:

Erythrityl tetranitrate is converted to an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3’,5’-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

Pharmacokinetics:

• Absorption: NA
• Distribution: N.A.
• Metabolism: NA
• Excretion: N.A.

1. https://go.drugbank.com/drugs/DB09235
2. https://pubchem.ncbi.nlm.nih.gov/compound/Erythrityl tetranitrate #section=MeSH-Pharmacological-Classification
3. https://www.medplusmart.com/product/efnocar-40mg-tab_efno0001