Ethyl Morphine

Ethyl Morphine is an antitussive belonging to opioid analgesic class.

Ethyl Morphine is an antitussive used as cough Suppressant.

Ethylmorphine is metabolized by the liver enzyme cytochrome P450 2D6 to morphine.

Ethyl Morphine shows common side effects like Blurred vision, Drowsiness or dizziness, Dryness of the mouth, Nausea or vomiting.

Ethyl Morphine is available in the form of Tablets (10 mg).

Ethyl Morphine is available in India, Germany, Canada, Italy.

Ethylmorphine is metabolized by the liver enzyme cytochrome P450 2D6 to morphine. The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. Morphine first acts on the mu-opioid receptors. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. It has been shown that morphine binds to and inhibits GABA inhibitory interneurons. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.

Ethyl Morphine is an antitussive used for the treatment of Pain management , acute and chronic pain. It is also used to treat Critically ill patients in the ICU (analgesia and sedation); Dyspnea in palliative care patients

Ethyl Morphine is approved for use in the following clinical indications

Respiratory depression, obstructive airway disease, asthma. Acute alcoholism, convulsive disorders, head injuries, comatose patients, raised intracranial pressure.

Enhanced depressant effects with alcohol, anaesthetics, anxiolytics, hypnotics, tricyclic antidepressants, antipsychotics. Possible CNS depression or excitation with MAOIs. May alter effects of other compounds eg, cyclizine, mexiletine, cisapride, metoclopramide and domperidone.

The common side effects of Ethyl Morphine include the following Blurred vision, Drowsiness or dizziness, Dryness of the mouth, Nausea or vomiting.

Pharmacodynamic

Ethylmorphine is metabolized by the enzyme cytochrome P450 2D6 to morphine. Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract

• https://www.rxlist.com/dopram-drug.htm
• https://www.mims.com/india/drug/info/Ethyl Morphine ?type=full&mtype=generic
• https://go.drugbank.com/drugs/DB00561
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003846/