Allopathy
Prescription Required
DCGI (Drugs Controller General of India)
Schedule H
Fenbufen is Non- Steroidal Anti inflammatory Drugs belonging to Analgesic and Anti inflammatory agents.
Fenbufen is used in the treatment of pain and inflammation in rheumatic disease and other musculoskeletal disorders.
Fenbufen is Absorbed from the GI tract and Enters breast milk (small amounts) with Plasma protein binding of >99%.
and get metabolised in the liver to active metabolites, biphenylacetic acid and 4-hydroxy-biphenylbutyric acid and get excreted Via urine (mainly as conjugates). Plasma half-life: Approx 10-17 hr.
The onset of action of Fenbufen was within 1 hour.
The Tmax of Fenbufen was within 2 hours
Fenbufen shows common side effects like Depression, dizziness, headache, numbness.
Fenbufen is available in Tablet and Capsule.
Fenbufen is available in India, Germany, Canada, France, USA.
Fenbufen is a propionic acid derivative which prevents the synthesis of prostaglandins by inhibiting cyclooxygenase.
Fenbufen is available in the form of tablets and Capsules.
Fenbufen is used in the treatment of pain and inflammation in rheumatic disease and other musculoskeletal disorders.
Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.
Fenbufen is approved for use in the following clinical indications
Pain and inflammation in rheumatic disease and other musculoskeletal disorders.
Oral:
Children <14 years: Not recommended
Adults: 300 mg in the morning and 600 mg at bedtime or 450 mg twice daily.
Fenbufen is available in the dosage strength of 300 mg, 450 mg.
Fenbufen is available in the form of Tablets and Capsules.
Fenbufen is contraindicated in patients with:
Hypersensitivity to fenbufen or other NSAIDs. Lactation.
- Common Adverse effects:
Depression, dizziness, headache, numbness.
- Less Common Adverse effects:
Anorexia, vomiting, abdominal pain, heartburn, diarrhea, black stool, constipation, dry/sore mouth.
- Rare Adverse effects
Rash, toxic epidermal necrolysis, oedema, photosensitivity.
Decreased serum concentration w/ aspirin. Risk of convulsions when given w/ quinolones (e.g. enoxacin, ofloxacin). May enhance the anticoagulant effect of coumarins.
The common side effects of Fenbufen include the following :
Renal effects (e.g. glomerular nephritis, interstitial nephritis, renal papillaryz necrosis, nephrotic syndrome, acute renal failure), increase SGOT and SGPT, Drowsiness, headache, dizziness, vertigo, restlessness, Anxiety, insomnia.
- Pharmacodynamic
Fenbufen is a propionic acid derivative which prevents the synthesis of prostaglandins by inhibiting cyclooxygenase.
- Pharmacokinetics
Absorption Absorbed from the GI tract. Time to peak plasma concentration: Approx 70 min.
Distribution: Enters breast milk (small amounts). Plasma protein binding: >99%.
Metabolism: Metabolised in the liver to active metabolites, biphenylacetic acid and 4-hydroxy-biphenylbutyric acid.
Excretion: Via urine (mainly as conjugates). Plasma half-life: Approx 10-17 hr.
- https://pubmed.ncbi.nlm.nih.gov/1091001/
- https://clinicaltrials.gov/ct2/show/NCT01422915
- https://clinicaltrials.gov/ct2/show/NCT02263547
- https://www.medicines.org.uk/emc/product/128/smpc.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/
- https://reference.medscape.com/drug/colestid-Fenbufen -342452
- https://go.drugbank.com/drugs/DB00375
- https://www.sciencedirect.com/topics/medicine-and-dentistry/Fenbufen
- https://europepmc.org/article/med/6988203
