Glycerine

Glycerine belongs to the pharmacological class of Hyperosmotic laxatives.Glycerinehas been approved for relieving symptoms and for treating and maintaining episodes of constipation, Dermatitis, Acts as a humectant in cough syrups, Used to treat certain conditions in which there is found to be an increased eye pressure, such as glaucoma. It might also be used before eye surgery to reduce pressure in the eye.

Glycerine is found to be well absorbed orally. Glycerin is well distributed across the blood. Approximately 7-14% of Glycerin has been found to be excreted unchanged in the urine within 2.5 hr.

The common side effects associated with Glycerine are Rectal irritation, cramping rectal pain, excessive bowel activity, cramping, irritation of skin, redness, and itching of skin.

Glycerine is found to be available in the form of Oral granules and oral tablets.

Glycerine is available in the U.S., Canada, E.U., India, Australia, and Japan.

Glycerine belongs to the pharmacological class of Hyperosmotic laxatives.

Glycerine, when administered rectally exerts a hygroscopic or local irritant action, by drawing water from the tissues into the feces as well as reflexively stimulating evacuation. Glycerin also decreases the intraocular pressure by creating an osmotic gradient between the blood as well as intraocular fluid, causing fluid to move out of the aqueous as well as vitreous humors into the bloodstream.

Glycerine had been approved for relieving symptoms as well as for the treatment and maintenance of episodes of Constipation, Dermatitis; It Acts as a humectant in cough syrups, used to treat certain conditions in which there is an increased eye pressure, such as glaucoma. It might also be used before eye surgery to reduce pressure in the eye.

Glycerine is available in the form of solutions, topical sprays and rectal suppository

The onset of action of Glycerin is 15 to30 minutes.

Glycerine is available in the form of solutions, topical spray and rectal suppository.

Glycerine can be used in the treatment of the following conditions:

• Constipation
• Dermatitis
• Acts as a humectant in cough syrups
• Used to treat certain conditions in which there is an increased eye pressure, such as glaucoma. It might also be used before eye surgery to reduce pressure in the eye.

Glycerine can help to relieve symptoms and also for the treatment and maintenance of constipation, Dermatitis, Acts as a humectant in cough syrups, Used to treat certain conditions in which there is an increased eye pressure, such as glaucoma. It might also be used before eye surgery to reduce pressure in the eye.

Glycerine is approved for use in the following clinical indications/conditions:

• Constipation
• Dermatitis
• Acts as a humectant in cough syrups
• Used to treat certain conditions in which there is an increased eye pressure, such as glaucoma. It might also be used before eye surgery to reduce pressure in the eye.

Solutions: To be applied directly on the affected area

Topical Spray: To be sprayed on the affected area

Rectal suppository : To be inserted rectally as directed by the physician.

Constipation

Adult

2-2.8 g suppository, retain 15 minutes, as needed constipation

Children 2-6 years

1-1.7 g suppository, retain 15 minutes, as needed constipation

Children over 6 years

2-8 g suppository, retain 15 minutes, as needed constipation

For oral dosage form (oral solution):

To lower pressure in the eye:

Adults—The usual dose is 1 to 2 g per kg of body weight taken one time. An of 500 mg per kg of body weight every 6 hours may be taken if needed.

Children— The usual dose is 1 to 1.5 g per kg of body weight taken once. The dose might be repeated in 4 to 8 hours if needed.

Solutions, Topical Spray, rectal suppository.

No specific dietary restrictions have been stated in the studies.

There are found to be no contraindications regarding the use of Glycerine.

No specific warnings and precautions has been reported with the use of Glycerin.

Glycerin falls into category C:

In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

The adverse reactions related to Glycerine can be categorized as follows:

• Rectal irritation
• Cramping rectal pain
• Excessive bowel activity
• Cramping
• Irritation of skin
• Redness
• Itching of skin

No clinically relevant drug interactions of Glycerine have been reported.

The common side effects of Glycerine include the following:

● Rectal irritation

● Cramping rectal pain

● Excessive bowel activity

● Cramping

● Irritation of skin

● Redness

● Itching of skin

Pregnancy

Glycerin falls into category C:

In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Pharmacodynamics

Glycerin is found to be commonly classified as an osmotic laxative but might act additionally or alternatively through its local irritant effects; it might also have lubricating and fecal softening actions. Glycerin suppositories usually work within about 15 to 30 minutes.

Pharmacokinetics

• Absorption

Glycerin is well absorbed orally, poorly absorbed rectally. Studies in humans as well as animals indicated that glycerol is rapidly absorbed in the intestine and the stomach

• Distribution

Glycerin is found to be distributed throughout the blood. Although Glycerin generally does not appear in ocular fluids, it might enter the orbital sac when the eye gets inflamed, with a consequent decrease in the osmotic effect.

• Metabolism

N.A.

• Elimination

Approx 7-14% of the dose is excreted unchanged in the urine within 2.5 hr.

1. https://www.webmd.com/drugs/2/drug-20275/glycerin-topical/details#:~:text=This medicine may be harmful,or trouble breathing, call 911.
2. https://www.webmd.com/vitamins/ai/ingredientmono-4/glycerol#:~:text=When taken by mouth: Glycerol,redness, itching, and burning.
3. https://go.drugbank.com/drugs/DB09462
4. https://www.drugs.com/mtm/glycerin-rectal.html#side-effects
5. https://www.rxwiki.com/glycerol
6. https://www.rxlist.com/consumer_glycerin/drugs-condition.htm#what_is_glycerin_and_how_does_it_work
7. https://reference.medscape.com/drug/glycerin-342014#10
8. https://www.mayoclinic.org/drugs-supplements/glycerin-oral-route/proper-use/drg-20067747?p=1#:~:text=Descriptions,as determined by your doctor.