Isoetharine

Isoetharine belongs to the pharmacological class of Beta 2-adrenergic agonists. Isoetharine appears to have bronchodilating properties.

Isoetharine had been approved to relieve symptoms and treat and maintain episodes of asthma, emphysema, and bronchitis.

Isoetharine is available in Germany, India, and Japan.

Isoetharine belongs to the pharmacological class of Beta 2-adrenergic agonists. Isoetharine appears to have bronchodilating properties.

Isoetharine had been approved for relieving symptoms as well as for the treatment and maintenance of episodes of asthma, emphysema, and bronchitis.

The pharmacological effects of isoetharine are attributable to stimulation through beta-adrenergic receptors of intracellular adenylyl cyclase, the enzyme that helps to catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with the relaxation of bronchial smooth muscle as well as the inhibition of the release of mediators of immediate hypersensitivity from cells, especially from mast cells.

The common side effects associated with the use of Isoetharine are headache, dizziness, dry mouth, muscle tremors, nausea, taste impairment, throat dryness, and fast heartbeat.

Isoetharine is available in the form of an Oral inhalation solution.

The peak effect of Isoetharine is achieved in 5-15 minutes, and the duration of action lasts for 1-4 hours.

Isoetharine is available in the form of the Oral inhalation solution, which is to be administered 1 to 2 inhalations every 4 hours.

Isoetharine has been used in the treatment of the following conditions

• Asthma
• Emphysema
• Bronchitis

Isoetharine can help to relieve symptoms and also for the treatment and maintenance of asthma, emphysema, and bronchitis.

Isoetharine was used following clinical indications/conditions:

• Asthma
• Emphysema
• Bronchitis

Metered Dose Inhalers:

1. Remove the cap. Some caps must be squeezed at the sides to release it.

2. Check the dose counter of the device.

3. Hold the inhaler upright and shake well before use.

4. Breathe out gently away from the inhaler before inhaling.

5. Put the mouthpiece between teeth and close lips tightly

6. Breathe in slowly through your mouth and, at the same time, press down firmly on the canister slowly simultaneously

7. Take a slow and deep breath

8. Hold your breath for about 5 or 10 seconds or as long as comfortable

9. While holding your breath, remove the inhaler from the mouth

10. Breathe out gently away from the inhaler

11. Repeat all steps starting from step 3. If more than one dose is needed,

12. Replace the cap

Aerosol inhalation: 340 mcg/metered spray

Oral Inhalation solution

Smoking cessation and maintaining health are a must.

Caffeine should be avoided or limited to use as it might lead to the risk of nausea, palpitations, nervousness, rapid heartbeat, etc.

Alcohol intake should be avoided in patients, especially those with an underlying liver disorder or liver dysfunction.

A diet containing food with high sugar content and carbohydrates should be restricted. This includes jams, candies, pies, cakes, honey, cookies, chips, and bread. It is also advised to reduce or limit the intake of cholesterol and saturated fat and instead chooses lean meat,poultry,or fish.

The dietary restrictions should be individualized as per the patient's requirements.

Isoetharine may be contraindicated under the following conditions:

• Hypersensitivity to the ingredients of the medication.

The adverse reactions related to Isoetharine can be categorized as

• Sore Throat
• Vomiting
• Generalized Weakness
• Dry Mouth
• Irritation Of The Mouth
• Dizziness
• Muscle Tremors
• Taste Impairment
• Headache
• High Blood Pressure
• Difficulty Sleeping
• Throat Dryness
• Nausea
• Fast Heartbeat

The common side effects of Isoetharine include the following:

• Sore Throat
• Vomiting
• Generalized Weakness
• Dry Mouth
• Irritation Of The Mouth
• Dizziness
• Muscle Tremors
• Taste Impairment
• Headache
• High Blood Pressure
• Difficulty Sleeping
• Throat Dryness
• Nausea
• Fast Heartbeat

Pharmacodynamics

Isoetharine is said to be a relatively selective beta2-adrenergic bronchodilator. Isoetharine has been indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. Adrenergic bronchodilators are breathed in through the mouth to open up the bronchial air passages of the lungs.

1. https://www.webmd.com/drugs/2/index
2. https://go.drugbank.com/drugs/DB00221
3. https://www.drugfuture.com/chemdata/isoetharine.html
4. https://medlineplus.gov/druginfo/meds/a682862.html
5. https://www.drugs.com/mtm/isoetharine-inhalation.html#uses
6. https://www.syrianclinic.com/med/en/ProfDrugs/Isoetharinepd.html