Loxoprofen

Loxoprofen is a propionic acid derivative belonging to Non-Steroidal anti-inflammatory Drug

Loxoprofen is used in the treatment of Pain and inflammation associated with musculoskeletal and joint disorders

Loxoprofen is Readily and almost completely absorbed from the gastrointestinal tract. Food may decrease absorption. It is Distributed into synovial fluid and CNS. Crosses the placenta; enters breast milk (small amounts). Volume of distribution: 0.34-1.57 L/kg. Plasma protein binding: Approx 99% and get Metabolised in the liver into glucuronide conjugate form and metabolites (desmethyl, desbenzoyl, and desmethyl-desbenzoyl), and their glucuronides. Undergoes extensive enterohepatic circulation. It is Mainly excreted via urine (60%; 26% as unchanged drug and glucuronide conjugates); faeces (33%, mainly as metabolites; 1.5% as unchanged drug). Terminal elimination half-life: 2.6-11.2 hours.

Loxoprofen shows common side effects like Atrial fibrillation, atrial flutter, peripheral edema

Loxoprofen is available in tablets, patch.

Loxoprofen is available in India, Germany, Canada, France, USA.

Loxoprofen is a non-selective cyclooxygenase inhibitor. It works by reducing the synthesis of prostaglandins from arachidonic acid. It is a prodrug that is rapidly converted to its active metabolite after oral admin.

Loxoprofen is available in the form of tablets, patch

Loxoprofen is used in the treatment of Pain and inflammation associated with musculoskeletal and joint disorders 

Loxoprofen is non-steroidal anti-inflammatory medication (NSAID) indicated for pain and inflammation related to musculoskeletal and joint disorders. In addition to its effects on pain, it is an antipyretic and anti-inflammatory medication.

Loxoprofen is approved for use in the following clinical indications

Pain and inflammation associated with musculoskeletal and joint disorders.

Loxoprofen is available in the dosage strength of 60 mg.

Loxoprofen is available in the form of tablets, patch 

Take after eating and with a full glass of water to decrease gastric upset.

Loxoprofen is contraindicated in patients with:

Patients with a history of hypersensitivity to any ingredients of Loxoprofen.

• Patients with or with a history of aspirin-induced asthma (induction of asthmatic attack with nonsteroidal anti-inflammatory-analgesics, etc.) [May induce an aspirin- induced asthmatic attack.]

Possible increased risk of seizures when used with ciprofloxacin and norfloxacin. May also increase serum levels of warfarin, methotrexate, lithium salts and sulphonylurea derivatives.

The common side effects of Loxoprofen include the following :

headache. dizziness. vomiting. diarrhea. constipation. ringing in the ears.

1. https://pubmed.ncbi.nlm.nih.gov/1091001/

2. https://clinicaltrials.gov/ct2/show/NCT01422915

3. https://clinicaltrials.gov/ct2/show/NCT02263547

4. https://www.medicines.org.uk/emc/product/128/smpc.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364710/

2. https://reference.medscape.com/drug/colestid-Loxoprofen -342452

3. https://go.drugbank.com/drugs/DB00375

4. https://www.sciencedirect.com/topics/medicine-and-dentistry/Loxoprofen

5. https://europepmc.org/article/med/6988203