Allopathy
Prescription Required
DCGI (Drugs Controller General of India)
Schedule H
Mephentermine is an alpha-adrenergic receptor agonist belonging to antihypertensive agent.
Mephentermine is a sympathomimetic agent used in the treatment of hypotension.
Mephentermine is rapidly demethylated in the body followed by hydroxylation. Mephentermine is excreted via urine (as unchanged and metabolites); more rapid in acidic urine.
Mephentermine shows common side effects like Systemic hypertension (high blood pressure), anxiety, insomnia (difficulty in sleeping), CNS stimulation.
Mephentermine is available in the form of an Injectable solution.
Mephentermine is available in India, New Zealand, Canada, China, and Australia.
Mephentermine belongs to the antihypertensive agent acts as an alpha-adrenergic receptor agonist.
Mephentermine is an alpha-adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.
The Data of onset of action of Mephentermine is not available.
The duration of action of Mephentermine is about 4 hours.
The Tmax of Mephentermine is approximately 5-15 mins.
Mephentermine is available in the form of Injectable solution.
Mephentermine injectable solution is given via intravenous route.
Mephentermine is used for the maintenance of blood pressure levels in patients with low blood pressure states (hypotensive states). It is also used to correct blood pressure levels if the blood pressure levels drop following spinal anesthesia in pregnant patients.
Mephentermine is an alpha-adrenergic receptor agonist belonging to antihypertensive agent.
Mephentermine is an alpha-adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.
Mephentermine is approved for use in the following clinical indications
- Maintenance of blood pressure in hypotensive states
Mephentermine is a sympathomimetic agent used in the treatment of hypotension.
- Hypotension secondary to spinal anaesthesia in obstetric patients
Mephentermine is also used to correct blood pressure levels if the blood pressure levels drop following spinal anesthesia in pregnant patients.
- Maintenance of blood pressure in hypotensive states
Adult IV Dose: 30-45 mg as a single dose, repeated as necessary or followed by IV infusion of 0.1% mephentermine in 5% dextrose, rate and duration of administration will depend on patient's response.
- Hypotension secondary to spinal anaesthesia in obstetric patients
Adult IV Dose: 15 mg as a single dose, repeat if needed.
Mephentermine is available in various strengths as 30mg/1mL.
Mephentermine is available in the form of Injectable solution.
- Dosage Adjustment in Kidney Patient
Mephentermine is taken with caution if you have a history of kidney diseases/condition.
- Dosage Adjustment in Hepatic impairment Patient
Mephentermine is taken with caution if you have a history of liver diseases/conditions.
Mephentermine is contraindicated in patients with
- Hypotension caused by phenothiazines.
- Hypertension.
- Phaeochromocytoma.
Breast Feeding Warning
Mephentermine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be considered before receiving this medicine.
Pregnancy Warning
Mephentermine is not recommended for use in pregnant women unless necessary. Determine the appropriate course of treatment after evaluating all the risks and benefits associated with the use of Mephentermine.
Common Adverse effects
- Drowsiness, incoherence, hallucinations, convulsions, tachycardia. Fear, anxiety, restlessness, tremor, insomnia, confusion, irritability, and psychosis. Nausea, vomiting, reduced appetite, urinary retention, dyspnoea, weakness.
- Hypotensive agents
Mephentermine antagonizes the effect of hypotensive agents.
- MAOIs and TCAs
Mephentermine servers the effect of hypertension with MAOIs and possibly TCAs.
- Ergot alkaloids and Oxytocin
Mephentermine increases the vasoconstricting effects with ergot alkaloids, oxytocin.
The common side effects of Mephentermine include the following
Common
● Systemic hypertension (high blood pressure), anxiety, insomnia (difficulty in sleeping), CNS stimulation.
- Pregnancy
Pregnancy Category
Mephentermine is not recommended for use in pregnant women unless necessary. Determine the appropriate course of treatment after evaluating all the risks and benefits associated with the use of Mephentermine.
- Nursing Mothers
Mephentermine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be considered before receiving this medicine.
Pharmacodynamic
Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of Mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence.
Pharmacokinetics
- Absorption
Information is not available.
- Distribution
Information is not available.
- Metabolism and Excretion
Mephentermine is rapidly demethylated in the body followed by hydroxylation. Mephentermine is excreted via urine (as unchanged and metabolites); more rapid in acidic urine.
- Udhoji VN, Weil MH. Vasodilator action of a “pressor amine,” mephentermine (Wyamine), in circulatory shock. The American Journal of Cardiology. 1965 Dec 1;16(6):841-6.
- Mohta M, Agarwal D, Gupta LK, Tyagi A, Gupta A, Sethi AK. Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section. Anaesthesia and intensive care. 2008 May;36(3):360-4.
- Shah PJ, Agrawal P, Beldar RK. Intravenous norepinephrine and mephentermine for maintenance of blood pressure during spinal anaesthesia for caesarean section: An interventional double-blinded randomised trial. Indian journal of anaesthesia. 2020 Sep;64(Suppl 4):S235.
- https://www.webmd.com/drugs/2/drug-8808/mephentermine-injection/details
- https://emedicine.medscape.com/article/820918-overview
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